Zhang Pengfei, Pei Bing, Yi Chengxue, Akanyibah Francis Atim, Mao Fei
Department of Laboratory Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang 212002, Jiangsu, PR China; Institute of Hematology, Jiangsu University, Zhenjiang 212013, Jiangsu, PR China.
Department of Clinical Laboratory, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian 223800, Jiangsu, PR China.
Biochim Biophys Acta Mol Basis Dis. 2025 Feb;1871(2):167578. doi: 10.1016/j.bbadis.2024.167578. Epub 2024 Nov 19.
Inflammatory bowel disease (IBD) and colorectal cancer (CRC), as two of the major human intestinal diseases, provide challenges for the medical field. Suppressor of cytokine signaling 3 (SOCS3), a protein molecule that negatively regulates cytokine signaling through multiple pathways, is involved in the regulation of various inflammatory diseases and tumors. In IBD, SOCS3 acts on a variety of cells to repair mucosal damage and balance the immune response, including epithelial cells, macrophages, dendritic cells, neutrophils, and T cells. In CRC, SOCS3 is inextricably linked to tumor cell proliferation, invasion, metastasis, and drug resistance. Therefore, it is crucial to systematically investigate the pathogenic involvement of SOCS3 in IBD and CRC. This article reviews the mechanisms and pathways by which SOCS3 is involved in the inhibition of IBD and the mitigation of CRC, and details the therapeutic options for targeting SOCS3.
炎症性肠病（IBD）和结直肠癌（CRC）是人类两种主要的肠道疾病，给医学领域带来了挑战。细胞因子信号转导抑制因子3（SOCS3）是一种通过多种途径对细胞因子信号进行负调控的蛋白质分子，参与多种炎症性疾病和肿瘤的调节。在IBD中，SOCS3作用于多种细胞以修复黏膜损伤并平衡免疫反应，包括上皮细胞、巨噬细胞、树突状细胞、中性粒细胞和T细胞。在CRC中，SOCS3与肿瘤细胞的增殖、侵袭、转移和耐药性密切相关。因此，系统研究SOCS3在IBD和CRC中的致病作用至关重要。本文综述了SOCS3参与IBD抑制和CRC缓解的机制和途径，并详细介绍了针对SOCS3的治疗选择。
