爱泼斯坦-巴尔病毒相关的B细胞淋巴增殖性疾病和淋巴瘤：诊断重叠与特征界定
Epstein-Barr virus-associated B-cell lymphoproliferative disorders and lymphomas: Diagnostic overlaps and defining features.
作者信息
Volaric Ashley K, Fedoriw Yuri
机构信息
Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Lineberger Comprehensive Cancer Center, 160 Medical Drive, Brinkhouse-Bullitt Building, CB#7525, Chapel Hill, NC, 27599, USA.
出版信息
Hum Pathol. 2025 Feb;156:105697. doi: 10.1016/j.humpath.2024.105697. Epub 2024 Nov 19.
Abstract
This review explores four Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders (LPD) and lymphomas with significant diagnostic overlap: EBV(+) mucocutaneous ulcer (EBVMCU), EBV(+) polymorphic LPD, EBV(+) classic Hodgkin lymphoma (CHL), and EBV(+) diffuse large B-cell lymphoma (DLBCL). Each entity is compared for both overlapping and defining features of clinical presentation, morphology, immunohistochemical profile and EBV expression pattern and latency. Our aims for this review are to provide useful guidance to the practicing pathologist in the diagnosis of these EBV-associated entities.
摘要
本综述探讨了四种与爱泼斯坦-巴尔病毒（EBV）相关的具有显著诊断重叠的B细胞淋巴增殖性疾病（LPD）和淋巴瘤：EBV（+）黏膜皮肤溃疡（EBVMCU）、EBV（+）多形性LPD、EBV（+）经典型霍奇金淋巴瘤（CHL）和EBV（+）弥漫性大B细胞淋巴瘤（DLBCL）。对每个实体的临床表现、形态学、免疫组织化学特征以及EBV表达模式和潜伏状态的重叠和决定性特征进行了比较。我们进行本综述的目的是为执业病理学家在诊断这些与EBV相关的实体时提供有用的指导。
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