泌尿道原发性黑色素瘤：病例的临床病理研究及文献综述
Primary melanoma of the urinary tract: a clinicopathological study of cases and literature review.
作者信息
Wang Lisha, Wali Mohammed, Sun Yue
机构信息
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
出版信息
J Clin Pathol. 2025 Jun 19;78(7):443-448. doi: 10.1136/jcp-2024-209684.
AIM
Primary malignant melanomas in the bladder or urethra are exceedingly rare. Diagnosing these tumours presents substantial challenges due to their close resemblance in gross appearance and histology to urothelial carcinomas.
METHODS
A retrospective review of our department archives from 2000 to 2023 identified four cases of primary malignant melanoma in the urinary tract. Demographic and clinical data were extracted from electronic medical records.
RESULTS
This retrospective case series investigates the clinical presentations, histopathological characteristics, immunohistochemical profiles and molecular features of four unique cases of primary malignant melanoma in the bladder or urethra.
CONCLUSION
Our analysis aims to deepen the understanding of the diagnostic and management strategies for this extremely rare disease.
目的
膀胱或尿道原发性恶性黑色素瘤极为罕见。由于其大体外观和组织学与尿路上皮癌极为相似，诊断这些肿瘤面临重大挑战。
方法
对我们科室2000年至2023年的档案进行回顾性研究，确定了4例尿路原发性恶性黑色素瘤病例。从电子病历中提取人口统计学和临床数据。
结果
本回顾性病例系列研究了4例膀胱或尿道原发性恶性黑色素瘤独特病例的临床表现、组织病理学特征、免疫组化谱和分子特征。
结论
我们的分析旨在加深对这种极其罕见疾病的诊断和管理策略的理解。
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