Sakamoto S, Tsuji Y, Koga S, Ibayashi H
Hepatogastroenterology. 1986 Feb;33(1):9-10.
We treated a patient with idiopathic fatty liver of pregnancy and a subsequent uncomplicated pregnancy. She experienced general fatigue, nausea, vomiting and jaundice, and renal failure occurred in the third trimester of her first pregnancy. Liver biopsy revealed swollen hepatocytes with microvesicular changes in the cytoplasm. A diagnosis of idiopathic fatty liver of pregnancy was made. Following delivery of a dead fetus, she recovered completely and was discharged on the 30th hospital day. Eighteen months later, she became pregnant again and was delivered of a healthy male baby in the 39th week of gestation. Total bilirubin and transaminase levels were normal, and renal function tests revealed no significant changes during the course of the pregnancy. However, cholinesterase activity increased progressively from the 7th month, thereby suggesting a predisposition to idiopathic fatty liver of pregnancy.
我们治疗了一名患有妊娠特发性脂肪肝且随后妊娠过程无并发症的患者。她出现全身乏力、恶心、呕吐及黄疸，在首次妊娠的孕晚期发生了肾衰竭。肝脏活检显示肝细胞肿胀，细胞质有微泡样改变。诊断为妊娠特发性脂肪肝。死胎娩出后，她完全康复，并于住院第30天出院。18个月后，她再次怀孕，并在妊娠第39周分娩出一名健康男婴。整个孕期总胆红素和转氨酶水平正常，肾功能检查无明显变化。然而，胆碱酯酶活性从第7个月开始逐渐升高，提示有妊娠特发性脂肪肝的易患倾向。
