Braz Gabriel Lima, Vasconcelos Ana Carolina Uchoa, Gomes Ana Paula Neutzling, Calderipe Camila Barcellos, Soares Alini Cardoso
Diagnostic Center of Oral Diseases, Dental School, Federal University of Pelotas-UFPel, Pelotas, Rio Grande do Sul, Brazil.
Diagnostic Center of Oral Diseases, Dental School, Federal University of Pelotas-UFPel, Pelotas, Rio Grande do Sul, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2025 Feb;139(2):229-241. doi: 10.1016/j.oooo.2024.10.081. Epub 2024 Oct 30.
To systematically review available data regarding adenomatoid hyperplasia of minor salivary glands (AHMSG).
Electronic searches were performed in six databases and gray literature. The risk of bias was assessed using the Joanna Briggs Institute tool.
Forty studies reporting 121 cases of AHMSG were included. There is a male predominance (n = 72/64.29%), with individuals in their fourth and fifth decade of life being the most affected. The palate was the main anatomical location (n = 90/74.39%), and most lesions presented as single, asymptomatic nodules. The mean size of AHMSGs was 1.48 ± 0.77 cm, and the mean evolution time was 16.84 ± 25.67 months. Immunohistochemical evaluation in three cases (2.48%) showed a low labeling index for Ki-67 (n = 2/66.67%) and proliferating cell nuclear antigen (n = 1/33.33%).
AHMSG is an uncommon benign lesion with no tendency to recur after initial surgical removal. The main histological features include an abundant proliferation of glandular acini, occasional ductal dilation, and sometimes the presence of inflammatory infiltrate. Pathologists and clinicians should be aware of AHMSG, as it can closely resemble both benign and malignant salivary gland lesions.
系统回顾有关小涎腺腺瘤样增生（AHMSG）的现有数据。
在六个数据库和灰色文献中进行电子检索。使用乔安娜·布里格斯研究所工具评估偏倚风险。
纳入了40项报告121例AHMSG病例的研究。男性居多（n = 72/64.29%），40至50岁的个体受影响最大。腭部是主要的解剖部位（n = 90/74.39%），大多数病变表现为单个无症状结节。AHMSG的平均大小为1.48±0.77厘米，平均演变时间为16.84±25.67个月。三例（2.48%）的免疫组织化学评估显示Ki-67（n = 2/66.67%）和增殖细胞核抗原（n = 1/33.33%）的标记指数较低。
AHMSG是一种罕见的良性病变，初次手术切除后无复发倾向。主要组织学特征包括腺泡大量增生、偶尔的导管扩张，有时还有炎症浸润。病理学家和临床医生应了解AHMSG，因为它可能与良性和恶性涎腺病变极为相似。
