PIC分离PRC1介导的抑制作用。
PIC-king apart PRC1-mediated repression.
作者信息
Healy Evan, Bracken Adrian P
机构信息
Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
出版信息
Trends Genet. 2025 Jan;41(1):4-5. doi: 10.1016/j.tig.2024.10.013. Epub 2024 Nov 20.
Polycomb repressive complex 1 (PRC1) is an essential repressor of lineage-specific genes central to the establishment and preservation of cellular identity. Recent findings by Szczurek et al. show that the noncanonical form of PRC1 (ncPRC1), which mediates H2AK119ub1, promotes a deep OFF state at promoters by blocking transcription initiation.
多梳抑制复合体1（PRC1）是细胞身份确立和维持过程中对谱系特异性基因起关键作用的抑制因子。Szczurek等人最近的研究结果表明，介导H2AK119ub1的非经典形式的PRC1（ncPRC1）通过阻断转录起始，在启动子处促进深度关闭状态。
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