College of Life Sciences, Northwest University, Xi'an, 710069, China.
Department of Hepatobiliary Surgery, Xijing Hosptial, Fourth Military Medical University, Xi'an, 710032, China.
J Cancer Res Clin Oncol. 2024 Nov 22;150(12):508. doi: 10.1007/s00432-024-06038-0.
The liver, gallbladder, and pancreas constitute a critically important system of digestive and endocrine organs in the human body, performing essential and complex physiological functions. At present, diseases of this digestive system have a high incidence in the world and is a more common disease. However, osteopontin (OPN) plays a crucial role in common liver, pancreatic, and biliary diseases, and its mechanisms of action merit further exploration and study.
We performed an analysis to assess the role of osteopontin in liver, pancreatic, and biliary diseases, focusing on its significance in these conditions.
Osteopontin, a profoundly phosphorylated glycoprotein, can be utilized as a diagnostic marker for hepatocellular carcinoma and cholangiopathies. Additionally it assists in the treatment of non-alcoholic fatty liver disease and promotes the proliferation, migration, and invasion of pancreatic cancer cells. Furthermore, osteopontin regulates inflammatory responses in chronic pancreatitis.
This review offers a thorough analysis of the genetic and protein architecture of OPN, and elucidates the relationship between osteopontin and liver, pancreatic, and biliary diseases. Furthermore, exclusive focus is lavished on the potential utility of OPN as a biomarker and an innovative therapeutic target in the management of these disorder.
肝脏、胆囊和胰腺构成了人体重要的消化系统和内分泌器官，具有重要而复杂的生理功能。目前，该消化系统疾病在世界范围内发病率较高，是一种较为常见的疾病。然而，骨桥蛋白（OPN）在常见的肝、胰和胆疾病中起着至关重要的作用，其作用机制值得进一步探讨和研究。
我们进行了一项分析，以评估骨桥蛋白在肝、胰和胆疾病中的作用，重点关注其在这些疾病中的意义。
骨桥蛋白是一种高度磷酸化的糖蛋白，可作为肝细胞癌和胆管疾病的诊断标志物。此外，它有助于治疗非酒精性脂肪性肝病，并促进胰腺癌细胞的增殖、迁移和侵袭。此外，骨桥蛋白调节慢性胰腺炎的炎症反应。
本综述全面分析了 OPN 的遗传和蛋白质结构，并阐明了骨桥蛋白与肝、胰和胆疾病之间的关系。此外，还特别关注了 OPN 作为生物标志物和治疗这些疾病的创新治疗靶点的潜在用途。
