肺结核患者中TNFα基因型与强化期化疗疗效及空洞破坏大小形成的相关性
Association of the Genotype of TNFα with the Efficiency of the Intensive Phase of Chemotherapy and Formation of the Sizes of Destruction Cavities in Patients with Pulmonary Tuberculosis.
作者信息
Balobanova N P, Alymenko M A, Valiev R Sh, Valiev N R, Safonov Ya A, Lipatov V A, Polonikov A V, Ragulina V A, Mal G S, Kolomiets V M
机构信息
Synergy University, Moscow, Russia.
Kazan State Medical Academy - Branch of Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russian Federation, Kazan, Russia.
出版信息
Bull Exp Biol Med. 2024 Nov;178(1):65-67. doi: 10.1007/s10517-024-06283-w. Epub 2024 Nov 22.
The interrelation between the TNFα gene polymorphism and the effectiveness of the intensive phase of chemotherapy in patients with pulmonary tuberculosis, as well as the formation of diameter of the sizes of destruction cavities was studied. It was revealed that the most adverse course of the disease and a high frequency of formation of destruction cavities are associated with the GG genotype of the TNFα gene.
研究了肿瘤坏死因子α（TNFα）基因多态性与肺结核患者强化期化疗疗效以及空洞破坏灶大小形成之间的相互关系。结果显示，疾病最不利的病程以及空洞破坏灶的高形成频率与TNFα基因的GG基因型有关。
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