Nora Petnehazy, CPMCRI: California Pacific Medical Center Research Institute, USA, E-Mail:
J Frailty Aging. 2024;13(4):384-390. doi: 10.14283/jfa.2024.45.
Sarcopenia negatively impacts quality of life. It is unclear whether different measures of muscle size, strength, physical performance, and fitness have similar associations with quality of life.
To describe associations of sarcopenia metrics with quality of life outcomes.
Community-dwelling adults aged 70+ years participating in the SOMMA (Study of Muscle, Mobility and Aging) study, (N=875 ((women: 519, men:356)), age, years 76.3±5.0).
Two academic medical centers.
Measures included muscle size (MRI- muscle volume. D3Cr muscle mass); strength and power (grip strength, leg extension power and strength, stair climb); walking and physical performance (4m and 400m walk, SPPB (Short Physical Performance Battery), chair stand); fitness (VO2 peak); health related quality of life (EQ-5D); and anthropometrics (weight, height, and body mass index). Results were stratified by sex. Correlations, scatterplots and linear regression models described the association between various measures of sarcopenia and fitness with overall quality of life score (EQ5D VAS) as a continuous variable. We also quantified differences between sarcopenia and fitness measures by overall QOL (Quality of Life) as a categorical variable (low, medium, high) and by QOL subcomponents (pain and discomfort, problems with usual activities, mobility, anxiety and depression, and problems with self-care) using distributionally appropriate methods.
Walking tests and physical performance were most consistently (but modestly) associated with overall quality of life (r~0.2, p<.001) and its subcomponents. For both men and women, several sarcopenia and fitness measures were more strongly associated with pain and usual activity than other QOL components.
Poor performance, lower fitness and lower strength are related to worse quality of life, particularly pain, in older adults. Future studies should quantify these relationships longitudinally.
肌肉减少症会降低生活质量。目前尚不清楚肌肉大小、力量、身体表现和体能的不同测量指标与生活质量的关联是否相似。
描述肌肉减少症指标与生活质量结果的关联。
参与 SOMMA（肌肉、移动性和衰老研究）研究的 70 岁以上社区居住成年人，（N=875（（女性：519，男性：356）），年龄，岁 76.3±5.0）。
两个学术医疗中心。
包括肌肉大小（MRI-肌肉体积。D3Cr 肌肉质量）；力量和功率（握力、腿部伸展力量和力量、爬楼梯）；步行和身体表现（4m 和 400m 步行、SPPB（简短身体表现电池）、椅子站立）；体能（VO2 峰值）；健康相关生活质量（EQ-5D）；和人体测量学（体重、身高和体重指数）。结果按性别分层。描述了各种肌肉减少症和体能测量指标与整体生活质量评分（EQ5D VAS）作为连续变量之间的关联的相关性、散点图和线性回归模型。我们还通过整体 QOL（生活质量）作为分类变量（低、中、高）和通过 QOL 子组件（疼痛和不适、日常活动问题、移动性、焦虑和抑郁以及自我护理问题），使用适用于分布的方法来量化肌肉减少症和体能测量指标之间的差异。
步行测试和身体表现与整体生活质量（r~0.2，p<.001）及其子组件最一致（但适度）相关。对于男性和女性，几种肌肉减少症和体能测量指标与疼痛和日常活动的相关性强于其他 QOL 成分。
较差的表现、较低的体能和较低的力量与老年人较差的生活质量相关，尤其是疼痛。未来的研究应纵向量化这些关系。
