Shosuke Satake, MD, PhD, Department of Frailty Research, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan, Department of Geriatric Medicine, Hospital, National Center for Geriatrics and Gerontology, Obu, Japan, 7-430 Morioka-cho, Obu City, Aichi Prefecture, 474-8511, Japan, Phone: +81-562-46-2311, Fax: +81-562-44-8518, E-mail:
J Frailty Aging. 2024;13(4):529-533. doi: 10.14283/jfa.2024.63.
This study aimed to provide evidence regarding the clinical significance of assessing intrinsic capacity (IC).
Longitudinal study.
Frailty clinic.
351 disability-free outpatients aged ≥65 years.
Adverse health outcomes were a composite of adverse health outcomes, including mortality, emergency hospitalization, nursing home placement, and new certification or exacerbation for long-term care. We created a composite score based on five IC domains using assessment scales from the WHO ICOPE handbook, with the weights for each domain determined through confirmatory factor analysis.
The composite score of IC was inversely associated with adverse health outcomes within 1-year; the multivariable-adjusted odds ratio (95% confidence interval) was 0.20 (0.09-0.41) for the highest versus lowest tertile, and 0.63 (0.48-0.83) for each 1-point increment in IC score, respectively. Similar associations were observed for specific adverse health outcome, but not for mortality.
IC was inversely associated with subsequent adverse health outcomes in older outpatients, suggesting its prognostic value in routine geriatric practices. Considering the limited sample size, our findings need to be further confirmed.
本研究旨在为评估内在能力（IC）的临床意义提供证据。
纵向研究。
虚弱诊所。
351 名无残疾的 65 岁及以上门诊患者。
不良健康结果是包括死亡率、急诊住院、疗养院安置以及长期护理新认证或恶化在内的不良健康结果的综合指标。我们使用世界卫生组织 ICOPE 手册中的评估量表，根据五个 IC 领域创建了一个综合评分，每个领域的权重通过验证性因子分析确定。
IC 综合评分与 1 年内的不良健康结果呈负相关；多变量调整后的优势比（95%置信区间）为最高与最低三分位组为 0.20（0.09-0.41），IC 评分每增加 1 分分别为 0.63（0.48-0.83）。特定不良健康结果也存在类似的关联，但与死亡率无关。
IC 与老年门诊患者随后的不良健康结果呈负相关，表明其在常规老年病学实践中的预后价值。考虑到样本量有限，我们的发现需要进一步证实。
