Klimczak Jaclyn A, Abraham Manoj, Hu Shirley, Rousso Daniel E, Perkins Stephen, Hamilton Mark
Facial Surgery Institute of Boca Raton, Boca Raton, Florida, USA.
Mount Sinai Facial Plastic Surgery, Poughkeepsie, New York, USA.
Facial Plast Surg Aesthet Med. 2024 Nov 22. doi: 10.1089/fpsam.2024.0008.
Tranexamic acid (TXA) has the ability to reduce intraoperative bleeding and facilitate hemostasis in addition to its anti-inflammatory properties that can potentially aid in recovery among patients who underwent rhytidectomy. To compare postoperative ecchymosis in patients who underwent rhytidectomy with TXA added to the tumescent anesthetic. A multi-institutional, single-blind study was performed on patients who underwent rhytidectomy. The sidedness of the face was randomized to receive either local anesthetic with TXA or without, prior to incision for rhytidectomy. The primary outcome was postoperative ecchymosis that was graded by the surgeons at the 1 week postoperative time frame in standard photograph review. A total of 70 patients, mean age 62.1, were enrolled in the study. The surface area of postoperative ecchymosis at 1 week was shown to be significantly less on the side of the face that received local anesthetic infiltration prior to incision with TXA than the side that had local anesthetic without TXA ( < 0.001). These results were consistent with subjective measurements of postoperative ecchymosis graded at 1 week with two blinded investigators to the sidedness of the face that received TXA ( < 0.001). TXA may potentially facilitate a reduction in postoperative ecchymosis in patients undergoing rhytidectomy.
氨甲环酸（TXA）除了具有抗炎特性外，还能够减少术中出血并促进止血，这可能有助于接受除皱手术的患者康复。为了比较在肿胀麻醉中添加TXA的除皱手术患者术后瘀斑情况。对接受除皱手术的患者进行了一项多机构单盲研究。在进行除皱手术切口前，将面部一侧随机分配接受含TXA的局部麻醉或不含TXA的局部麻醉。主要结局是术后瘀斑，由外科医生在术后1周通过标准照片回顾进行分级。共有70名患者入组研究，平均年龄62.1岁。结果显示，在切口前接受含TXA局部麻醉浸润的面部一侧，术后1周瘀斑的表面积显著小于接受不含TXA局部麻醉的一侧（<0.001）。这些结果与两名对接受TXA的面部一侧不知情的调查人员在术后1周对瘀斑进行的主观测量结果一致（<0.001）。TXA可能有助于减少接受除皱手术患者的术后瘀斑。
