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用β-丙内酯处理的血清白蛋白在豚鼠中诱导致敏：接受人二倍体细胞狂犬病疫苗的人类发生过敏反应原因的实验证据。

Sensitization induced in guinea pigs with beta-propiolactone-treated serum albumin: experimental evidence for the cause of allergic reactions in humans receiving human diploid cell rabies vaccines.

作者信息

Levenbook I S, Merritt B A, Fitzgerald E A, Elisberg B L

出版信息

Int Arch Allergy Appl Immunol. 1986;80(1):110-1. doi: 10.1159/000234035.

DOI:10.1159/000234035
PMID:3957443
Abstract

beta-Propiolactone-treated (BPL-T) homologous serum albumin caused anaphylaxis in guinea pigs with a frequency and severity equal to that of guinea pigs inoculated with human albumin. Untreated guinea pig serum albumin did not cause any reactions in these animals. Some recipients of current rabies vaccine produced in human diploid cells available in the USA develop systemic allergic reactions, usually following booster immunization. The BPL-T human albumin component of the vaccines was believed to be the cause of the complications. Our studies support this conclusion.

摘要

经β-丙内酯处理（BPL-T）的同源血清白蛋白在豚鼠中引发过敏反应的频率和严重程度与接种人白蛋白的豚鼠相同。未经处理的豚鼠血清白蛋白在这些动物中未引发任何反应。美国现有的人二倍体细胞狂犬病疫苗的一些接种者会出现全身过敏反应，通常在加强免疫后发生。疫苗中的BPL-T人白蛋白成分被认为是并发症的原因。我们的研究支持这一结论。

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Sensitization induced in guinea pigs with beta-propiolactone-treated serum albumin: experimental evidence for the cause of allergic reactions in humans receiving human diploid cell rabies vaccines.用β-丙内酯处理的血清白蛋白在豚鼠中诱导致敏：接受人二倍体细胞狂犬病疫苗的人类发生过敏反应原因的实验证据。
Int Arch Allergy Appl Immunol. 1986;80(1):110-1. doi: 10.1159/000234035.
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