Zhang Peng, Xu Chenyang, Liu Zhijun, Geng Yadong, Liu Honglin
Department of Neurosurgery, Huaihe Hospital of Henan University, No.1, Baogonghubei Road, Gulou District, Kaifeng, 475000, Henan Province, China.
Mol Cell Biochem. 2025 May;480(5):2951-2970. doi: 10.1007/s11010-024-05160-4. Epub 2024 Nov 22.
Carotid artery stenosis is the main cause of cerebral watershed infarction (CWI). In recent years, increasing attention has been given to treating this condition. The present study aimed to investigate how Verteporfin-eluting stent (VPES) modulates the YAP signaling pathway to inhibit restenosis of the carotid artery and alleviate CWI. Through transcriptome sequencing and functional experiments, it was found that VP could regulate the Yes-associated protein (YAP) signaling pathway and effectively suppress the proliferation and migration of smooth muscle cells (SMCs). Further investigation revealed that VPES could inhibit carotid artery restenosis through the YAP signaling pathway in a rabbit model, reducing the occurrence of CWI.
颈动脉狭窄是脑分水岭梗死（CWI）的主要原因。近年来，对这种疾病的治疗越来越受到关注。本研究旨在探讨维替泊芬洗脱支架（VPES）如何调节YAP信号通路以抑制颈动脉再狭窄并减轻CWI。通过转录组测序和功能实验发现，维替泊芬（VP）可调节Yes相关蛋白（YAP）信号通路，并有效抑制平滑肌细胞（SMC）的增殖和迁移。进一步研究表明，在兔模型中，VPES可通过YAP信号通路抑制颈动脉再狭窄，减少CWI的发生。
