肿瘤细胞体外质子-中子联合辐照有效性研究

The Study of Effectiveness of Combined Proton-Neutron Irradiation of Tumor Cells In Vitro.

作者信息

Koryakin S N, Troshina M V, Koryakina E V, Potetnya V I, Pichkunova A A, Saburov V O, Kazakov E I, Lychagin A A, Ivanov S A, Kaprin A D, Zverev V I, Presnyakov A Yu

机构信息

A. Tsyb Medical Radiological Research Centre - Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia.

Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2024 Nov;178(1):75-78. doi: 10.1007/s10517-024-06285-8. Epub 2024 Nov 22.

DOI:10.1007/s10517-024-06285-8

PMID:39576473

Abstract

Combined proton-neutron therapy can be the best opportunity for neutron radiation therapy due to highly conformal proton irradiation and high relative biological effectiveness of neutrons. The study compares 4 schemes of sequential in vitro exposure of Chinese hamster fibrosarcoma cells B14-150 to 14.5 MeV neutrons and a scanning beam of protons. Treatment efficiency increased with increasing the contribution of the neutron component to the total dose from 30 to 40% and the delivery of the neutron dose as the first fraction in the two-fraction proton-neutron exposure.

摘要

由于质子照射具有高度适形性且中子具有较高的相对生物效应，质子 - 中子联合治疗可能是中子放射治疗的最佳契机。该研究比较了中国仓鼠纤维肉瘤细胞B14 - 150依次体外暴露于14.5 MeV中子和质子扫描束的4种方案。当中子成分在总剂量中的占比从30%增加到40%，且在质子 - 中子两分割照射中作为第一分割给予中子剂量时，治疗效果有所提高。