Korvyakova Ya E, Azarova I E, Markina D D, Churilin M I, Bushueva O Yu, Klyosova E Yu, Solodilova M A, Polonikov A V
Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
Bull Exp Biol Med. 2024 Nov;178(1):79-85. doi: 10.1007/s10517-024-06286-7. Epub 2024 Nov 22.
We studied the association of polymorphisms in the aminopeptidase N gene (ANPEP) with the development of diabetic retinopathy and nephropathy in patients with type 2 diabetes mellitus (T2DM). DNA samples from T2DM patients (n=1425) were genotyped for 23 single nucleotide polymorphisms (SNPs) using the MassARRAY system. Associations of SNP rs13380049 of the ANPEP gene with a lower risk of diabetic retinopathy (OR=0.54, 95%CI 0.36-0.82, p=0.0032) and nephropathy (OR=0.66, 95%CI 0.44-0.99, p=0.048) were found in T2DM patients. In addition, SNP rs25653 was associated with retinopathy, and polymorphisms rs6496608, rs72756574, rs9920421, and rs4932143 were associated with diabetic nephropathy. The study demonstrated the contribution of ANPEP gene polymorphisms in the determination of microvascular complications in T2DM patients.
我们研究了氨肽酶N基因（ANPEP）多态性与2型糖尿病（T2DM）患者糖尿病视网膜病变和肾病发生之间的关联。使用MassARRAY系统对1425例T2DM患者的DNA样本进行了23个单核苷酸多态性（SNP）的基因分型。在T2DM患者中发现，ANPEP基因的SNP rs13380049与较低的糖尿病视网膜病变风险（OR = 0.54，95%CI 0.36 - 0.82，p = 0.0032）和肾病风险（OR = 0.66，95%CI 0.44 - 0.99，p = 0.048）相关。此外，SNP rs25653与视网膜病变相关，多态性rs6496608、rs72756574、rs9920421和rs4932143与糖尿病肾病相关。该研究证明了ANPEP基因多态性在T2DM患者微血管并发症发生中的作用。
