Xiao Yao, Kandala Sri, Huang Jenny, Liu Jinyuan, McGonigle Trey, Barch Deanna, Tang Yangqing, Fan Guoguang, Wang Fei, Womer Fay Y
Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, 264 Guangzhou Rd, Nanjing, Jiangsu, 210029, China.
Department of Psychiatry, Washington University, 660 South Euclid Ave, St. Louis, MO, 63108, USA.
J Psychiatr Res. 2025 Jan;181:14-22. doi: 10.1016/j.jpsychires.2024.11.023. Epub 2024 Nov 9.
The cerebellar vermis is implicated in cognition and emotion, two key components of the psychotic-affective spectrum that includes schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD).
Volumes [N = 391; 97 SCZ, 78 BD, 103 MDD, and 113 healthy controls (HC)] and seed-to-whole brain functional connectivity (FC) [N = 136; 33 SCZ, 23 BD, 51 MDD, and 29 HC] of total vermis and its subregions, V1 (anterior), V2 (posterior superior), and V3 (posterior inferior), were examined across SCZ, BD, MDD, and HC in samples enriched for first episode individuals. The relationship between vermis volumes and FC and cognitive measures were explored.
Significant diagnosis (p = 0.05) and diagnosis by subregion (p = 0.02) effects on vermis volumes were observed across the four groups, particularly in V2 (p = 0.01) with decreased V2 volumes in SCZ compared to BD (p = 0.01). SCZ, BD, and MDD had significant effects on vermis FC, with SCZ having the greatest effects. SCZ had effects on FC of V1, V2, and V3 with broadly distributed cortical and subcortical regions, while BD and MDD effects were observed in FC of V2 and V3 with frontotemporal regions. Exploratory analyses found significant canonical correlation between V3 FC and WM and visual learning for SCZ and MDD. No significant associations were shown between vermis volumes and cognitive measures.
Structural and functional alterations of the vermis appear to vary across the psychotic-affective spectrum of SCZ, BD, and MDD. Posterior vermis may be a key neural intersection between affective and psychotic psychopathology.
小脑蚓部与认知和情绪有关，认知和情绪是精神分裂症（SCZ）、双相情感障碍（BD）和重度抑郁症（MDD）等精神情感谱系的两个关键组成部分。
在以首发个体为主的样本中，对SCZ、BD、MDD和健康对照（HC）组共391名受试者（97名SCZ、78名BD、103名MDD和113名HC）的小脑蚓部及其亚区域V1（前部）、V2（后部上半）和V3（后部下半）的体积以及种子点到全脑的功能连接（FC）[共136名受试者；33名SCZ、23名BD、51名MDD和29名HC]进行了检查。探讨了蚓部体积、FC与认知指标之间的关系。
四组之间在蚓部体积上观察到显著的诊断效应（p = 0.05）和按亚区域的诊断效应（p = 0.02），特别是在V2区域（p = 0.01），与BD相比，SCZ的V2体积减小（p = 0.01）。SCZ、BD和MDD对蚓部FC有显著影响，其中SCZ的影响最大。SCZ对V1、V2和V3与广泛分布的皮质和皮质下区域的FC有影响，而BD和MDD对V2和V3与额颞区域的FC有影响。探索性分析发现，SCZ和MDD的V3 FC与工作记忆和视觉学习之间存在显著的典型相关性。蚓部体积与认知指标之间未显示出显著关联。
小脑蚓部的结构和功能改变在SCZ、BD和MDD的精神情感谱系中似乎有所不同。小脑蚓部后部可能是情感和精神性精神病理学之间的关键神经交汇点。
