Pereira Moises Dantas Cartaxo de Abreu, Hilário Fabrine Felipe, Campana Eloiza Helena, Sousa Eduardo Sergio Soares, Perez Vinicius Pietta
Universidade Federal da Paraíba (UFPB), Centro de Ciências Médicas (CCM), Mestrado Profissional em Saúde da Família, João Pessoa, PB, Brazil.
Universidade Federal da Paraíba (UFPB), Centro de Ciências Médicas (CCM), Laboratório de Biologia Molecular (LaBiMoL), João Pessoa, PB, Brazil.
Braz J Infect Dis. 2024 Nov-Dec;28(6):104469. doi: 10.1016/j.bjid.2024.104469. Epub 2024 Nov 21.
Group B Streptococcus (GBS) is a significant pathogen responsible for neonatal infections, primarily transmitted through maternal carriage. However, current preventive strategies, such as intrapartum antibiotic prophylaxis, present limitations and are ineffective in preventing late-onset neonatal infections. This study aimed to assess the prevalence and serotype distribution of GBS in the nasopharynx of women of reproductive age, providing data to the potential implementation of a novel hexavalent capsular vaccine (GBS6). Nasopharyngeal swabs were collected from 500 women and analyzed using a qPCR assay targeting the cfb gene to detect GBS and the cps locus. GBS was identified in 7.4 % of patients, with serotype Ia being the most prevalent. Other serotypes detected included II, V, Ib, III, and IV. These findings suggest that the nasopharynx may act as a reservoir for GBS in women of reproductive age. The results also highlight the importance of developing preventive strategies focused on upper respiratory tract colonization. Additionally, the potential introduction of the GBS6 vaccine could provide significant coverage against circulating GBS serotypes.
B族链球菌（GBS）是导致新生儿感染的重要病原体，主要通过母体携带传播。然而，目前的预防策略，如产时抗生素预防，存在局限性，且在预防晚发型新生儿感染方面效果不佳。本研究旨在评估育龄妇女鼻咽部GBS的流行情况和血清型分布，为新型六价荚膜疫苗（GBS6）的潜在应用提供数据。从500名妇女中采集鼻咽拭子，并使用针对cfb基因的qPCR检测法来检测GBS和cps位点。7.4%的患者检测出GBS，其中血清型Ia最为常见。检测到的其他血清型包括II、V、Ib、III和IV。这些发现表明，鼻咽部可能是育龄妇女GBS的储存部位。研究结果还凸显了制定针对上呼吸道定植的预防策略的重要性。此外，GBS6疫苗的潜在引入可为流行的GBS血清型提供显著的覆盖范围。
