Li Danyang, Liu Yanyan, Yang Guang, He Mingyu, Lu Ligong
Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai Clinical Medical College of Jinan University (Zhuhai People's Hospital), Zhuhai, Guangdong Province 519000, PR China.
Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai Clinical Medical College of Jinan University (Zhuhai People's Hospital), Zhuhai, Guangdong Province 519000, PR China.
Biochim Biophys Acta Rev Cancer. 2024 Nov;1879(6):189223. doi: 10.1016/j.bbcan.2024.189223. Epub 2024 Nov 20.
RNA 5-methylcytosine (m5C) methylation involves the addition of a methyl (-CH3) group to the cytosine (C) base within an RNA molecule, forming the m5C modification. m5C plays a role in numerous essential biological processes, including the regulation of RNA stability, nuclear export, and protein translation. Recent studies have highlighted the importance of m5C in the pathogenesis of various diseases, particularly tumors. Emerging evidence indicates that RNA m5C methylation is intricately implicated in the mechanisms underlying hepatocellular carcinoma (HCC). Dysregulation of m5C-associated regulatory factors is common in HCC and shows significant associations with prognosis, treatment response, and clinicopathological features. This review provides an in-depth analysis of the components and functions of m5C regulators, particularly emphasizing their research advancements in the context of HCC.
RNA 5-甲基胞嘧啶（m5C）甲基化是指在RNA分子中的胞嘧啶（C）碱基上添加一个甲基（-CH3）基团，形成m5C修饰。m5C在众多重要的生物学过程中发挥作用，包括RNA稳定性调控、核输出和蛋白质翻译。最近的研究突出了m5C在各种疾病，尤其是肿瘤发病机制中的重要性。新出现的证据表明，RNA m5C甲基化与肝细胞癌（HCC）的潜在机制密切相关。m5C相关调控因子的失调在HCC中很常见，并且与预后、治疗反应和临床病理特征显著相关。本综述对m5C调控因子的组成和功能进行了深入分析，特别强调了它们在HCC背景下的研究进展。
