Uthayo Warisa, Chunin Hathaichanok, Sudnawa Khemika K, Arunyanart Wirongrong, Phatarakijnirund Voraluck
Division of Pediatric Endocrinology, Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.
Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.
J Pediatr Endocrinol Metab. 2024 Nov 25;38(2):102-109. doi: 10.1515/jpem-2024-0186. Print 2025 Feb 25.
Idiopathic central precocious puberty (iCPP) is the most common cause of precocious puberty in girls. However, research on the psychological outcomes of iCPP girls is limited. To evaluated the psychological characteristics in iCPP girls in comparison to prepubertal girls throughout the first diagnosis and six-month follow-up period.
Eighty-five girls, age 6-8 years, and their caregivers were enrolled to the prospective cohort study. Three Thai-standardized questionnaires were used as psychological assessment tools, including Children's Depression Inventory (CDI), Parent Screen for Child Anxiety Related Disorders (SCARED) and Parent-Strengths and Difficulties Questionnaire (SDQ).
Forty-six iCPP and 39 prepuberty girls were enrolled at baseline. No significant differences in psychological and behavioral problems between iCPP and prepuberty girls. However, the iCPP group exhibited a significantly higher proportion of "risk and problem" for emotional problems compares to the prepuberty group (7 vs. 0, p=0.01) while the prepuberty group exhibits the significantly proportion of "risk" for peer problems (6 vs. 0, p=0.007). At baseline, twelve percent of iCPP girls exhibited depression and mean CDI score was 8.1 ± 7.2 and 3.7 ± 2.3 (p=0.007) in iCPP and prepuberty group, respectively. At the 6-month follow-up, there was no significant difference in psychological outcomes between two groups.
There were no significant differences in psychological and behavioral problems in iCPP girls compared to prepubertal girls. However, the higher prevalence of emotional problems and depression observed in iCPP girls constitutes significant psychological issues that necessitate close monitoring.
特发性中枢性性早熟（iCPP）是女孩性早熟最常见的原因。然而，关于iCPP女孩心理结局的研究有限。本研究旨在评估iCPP女孩在首次诊断及六个月随访期间相较于青春期前女孩的心理特征。
85名6至8岁的女孩及其照顾者被纳入前瞻性队列研究。使用三份泰国标准化问卷作为心理评估工具，包括儿童抑郁量表（CDI）、儿童焦虑相关障碍家长筛查量表（SCARED）和家长版长处与困难问卷（SDQ）。
46名iCPP女孩和39名青春期前女孩在基线时入组。iCPP女孩和青春期前女孩在心理和行为问题方面无显著差异。然而，与青春期前女孩相比，iCPP组在情绪问题方面出现“风险和问题”的比例显著更高（7比0，p = 0.01），而青春期前组在同伴问题方面出现“风险”的比例显著更高（6比0，p = 0.007）。在基线时，12%的iCPP女孩表现出抑郁，iCPP组和青春期前组的CDI平均得分分别为8.1±7.2和3.7±2.3（p = 0.007）。在6个月随访时，两组的心理结局无显著差异。
与青春期前女孩相比，iCPP女孩在心理和行为问题方面无显著差异。然而，iCPP女孩中观察到的情绪问题和抑郁的较高患病率构成了重大心理问题，需要密切监测。
