Zhang Baoyi, Zhang Ni, Zhang Ye, Yan Jingwen, Chen Lili, He Haiyan, Sun Shihao, Zhang Yiheng, Zhang Meifen
School of Nursing, Sun Yat-sen University, Guangzhou, China.
Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Eur J Oncol Nurs. 2025 Feb;74:102735. doi: 10.1016/j.ejon.2024.102735. Epub 2024 Nov 16.
Chemotherapy-induced taste alterations (CiTA) are significant predictors of gastrointestinal symptoms, malnutrition, and poor prognosis. However, the prevalence and risk factors of CiTA vary substantially between studies. This study aimed to synthesize the prevalence and risk factors of CiTA among cancer patients.
Eight databases (Pubmed, Web of Science, Embase, ScienceDirect, Sinomed, China National Knowledge Infrastructure, Wanfang and Weipu database) were retrieved to collect observational studies regarding the prevalence or risk factors of CiTA published before June 1, 2024. The random effects meta-analysis was conducted to estimate the pooled prevalence. Subgroup analysis was conducted to identify heterogeneity across studies. For the same risk factor, the odds ratio and 95% confidence interval were calculated.
In total, 30 studies with 15,722 participants were included. The pooled prevalence of CiTA was 70.0% (95% CI: 59.1%-79.9%, I = 99.4%), ranging from 21.0% to 100.0%. Female (OR = 2.59, 95% CI: 1.59 to 4.22), patients with xerostomia (OR = 2.04, 95% CI: 1.48 to 2.81), oral mucositis/ulcers (OR = 3.72, 95% CI: 1.46 to 9.47), receiving not less than 2 chemotherapy cycles (OR = 3.95, 95% CI: 3.20 to 4.88) were more likely to develop CiTA.
The prevalence of CiTA among cancer patients was alarmingly high. Female, xerostomia, oral mucositis/ulcers, receiving not less than 2 chemotherapy cycles were significant risk factors of CiTA. Healthcare practitioners should identify high-risk patients and develop targeted interventions to manage CiTA based on identified risk factors.
化疗引起的味觉改变（CiTA）是胃肠道症状、营养不良和不良预后的重要预测指标。然而，不同研究中CiTA的患病率和危险因素差异很大。本研究旨在综合分析癌症患者中CiTA的患病率和危险因素。
检索了八个数据库（PubMed、Web of Science、Embase、ScienceDirect、中国生物医学文献数据库、中国知网、万方和维普数据库），以收集2024年6月1日前发表的关于CiTA患病率或危险因素的观察性研究。采用随机效应荟萃分析来估计合并患病率。进行亚组分析以识别不同研究之间的异质性。对于相同的危险因素，计算比值比和95%置信区间。
共纳入30项研究，涉及15722名参与者。CiTA的合并患病率为70.0%（95%CI：59.1%-79.9%，I²=99.4%），范围从21.0%到100.0%。女性（OR=2.59，95%CI：1.59至4.22）、口干患者（OR=2.04，95%CI：1.48至2.81）、口腔黏膜炎/溃疡患者（OR=3.72，95%CI：1.46至9.47）、接受不少于2个化疗周期的患者（OR=3.95，95%CI：3.20至4.88）更易发生CiTA。
癌症患者中CiTA的患病率高得惊人。女性、口干、口腔黏膜炎/溃疡、接受不少于2个化疗周期是CiTA的重要危险因素。医疗从业者应识别高危患者，并根据已确定的危险因素制定针对性干预措施来管理CiTA。
