Praud Delphine, Amadou Amina, Coudon Thomas, Duboeuf Margaux, Mercoeur Benoît, Faure Elodie, Grassot Lény, Danjou Aurélie Mn, Salizzoni Pietro, Couvidat Florian, Dossus Laure, Severi Gianluca, Mancini Francesca Romana, Fervers Béatrice
Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France; Inserm, U1296 Unit, "Radiation: Defense, Health and Environment", Lyon, France.
Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France; Inserm, U1296 Unit, "Radiation: Defense, Health and Environment", Lyon, France.
Int J Hyg Environ Health. 2025 Jan;263:114489. doi: 10.1016/j.ijheh.2024.114489. Epub 2024 Nov 22.
Breast cancer is the most common type of cancer among women. Environmental pollutants, specifically those with endocrine disrupting properties like dioxins, may impact breast cancer development. Current epidemiological studies on the association between exposure to dioxins and the risk of breast cancer show inconsistent results. To address these uncertainties, our objective was to investigate the impact of airborne dioxin exposure on breast cancer risk within the E3N cohort, encompassing 5222 cases identified during the 1990-2011 follow-up and 5222 matched controls. Airborne dioxin exposure was assessed using a Geographic Information System-based metric considering residential proximity to dioxin emitting sources, their technical characteristics, exposure duration and wind direction. Additional analyses were performed using dioxin concentrations estimated by a chemistry transport model, CHIMERE. The results suggest a slightly increased risk between cumulative dioxin exposure at the residential address and overall breast cancer risk (adjusted odds ratio (OR) = 1.03, 95% confidence interval (CI): 0.99-1.07, for a one standard deviation (SD) increment among controls (14.47 log-μg-TEQ/m). The associations remained consistent for sources within 3, 5, and 10 km, and when restricting exposure to dioxin emissions from household waste incinerators. Similar OR estimates (OR = 1.02, 95% CI: 0.97-1.07, for a one SD increment) were obtained using the CHIMERE model. The findings of this study suggest the possibility of an increased risk of breast cancer associated with long-term residential exposure to dioxins and emphasize the importance of efforts to mitigate air pollution exposure.
乳腺癌是女性中最常见的癌症类型。环境污染物，特别是那些具有内分泌干扰特性的物质，如二恶英，可能会影响乳腺癌的发展。目前关于接触二恶英与乳腺癌风险之间关联的流行病学研究结果并不一致。为了解决这些不确定性问题，我们的目标是在E3N队列中调查空气中二恶英暴露对乳腺癌风险的影响，该队列包括在1990 - 2011年随访期间确定的5222例病例和5222例匹配对照。使用基于地理信息系统的指标评估空气中二恶英暴露情况，该指标考虑了住宅与二恶英排放源的距离、排放源的技术特征、暴露持续时间和风向。还使用化学传输模型CHIMERE估算的二恶英浓度进行了额外分析。结果表明，居住地址的累积二恶英暴露与总体乳腺癌风险之间的风险略有增加（调整后的优势比（OR）= 1.03，95%置信区间（CI）：0.99 - 1.07，对照组中一个标准差（SD）增量为（14.47 log-μg-TEQ/m））。对于3公里、5公里和10公里范围内的排放源，以及限制暴露于来自生活垃圾焚烧炉的二恶英排放时，这种关联仍然一致。使用CHIMERE模型也获得了类似的OR估计值（OR = 1.02，95% CI：0.97 - 1.07，一个SD增量）。这项研究的结果表明，长期居住暴露于二恶英可能会增加患乳腺癌的风险，并强调了努力减少空气污染暴露的重要性。
