Ohashi Toshio, Ito Rintaro, Yamamoto Ryo, Ukai Katsuyuki, Naganawa Shinji
Department of Radiology, Kamiiida Daiichi General Hospital, Nagoya, Aichi, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Magn Reson Med Sci. 2024 Nov 23. doi: 10.2463/mrms.mp.2024-0138.
A cyst-like structure near superior sagittal sinus (Arachnoid Cuff Exit Site cysts: ACES cysts) has been reported in MRI. The purpose of this study was to investigate the association between presence of ACES cysts and cognitive function, as assessed using mini-mental state examination (MMSE) scores.
We retrospectively analyzed patients who underwent head MRI for dementia screening. Differences in patient ages and MMSE scores between patients with and without ACES cysts were examined using the Mann-Whitney U test. Correlations between patient ages and MMSE scores were examined for patients with and without ACES cysts using Spearman's rank correlation coefficient. Multivariate logistic regression analysis was performed to examine the influence of presence or absence of ACES cysts on MMSE score.
A total of 112 patients (male: 28, female: 84) were included for the analysis. The patient ages ranged from 66 to 94 years (median: 83 years). MMSE scores ranged from 6 to 30 (median: 24). ACES cysts were detected in 57 patients (50.9%). There was no significant difference in patient ages between the patients with and without ACES cysts (P = 0.058). The patients with ACES cysts showed significantly lower MMSE scores compared to the patients without ACES cysts (P < 0.001). In the patients with ACES cysts, there was no significant correlation between patient ages and MMSE scores (ρ = -0.178, P = 0.185), whereas a significant negative correlation was observed in the patients without ACES cysts (ρ = -0.347, P = 0.001). The presence of ACES cysts was determined as an independent predictor for the lower MMSE score (odds ratio = 15.2, 95% confidence interval = 5.59-41.4, P < 0.001).
The presence of the ACES cysts showed significant association with lower MMSE score. ACES cysts might be involved in the pathological processes affecting cognitive function.
MRI检查发现上矢状窦附近存在一种囊肿样结构（蛛网膜袖套出口处囊肿：ACES囊肿）。本研究旨在通过简易精神状态检查表（MMSE）评分来调查ACES囊肿的存在与认知功能之间的关联。
我们回顾性分析了因痴呆筛查而接受头部MRI检查的患者。使用Mann-Whitney U检验比较有和没有ACES囊肿患者的年龄及MMSE评分差异。使用Spearman等级相关系数检验有和没有ACES囊肿患者的年龄与MMSE评分之间的相关性。进行多因素逻辑回归分析以检验ACES囊肿的有无对MMSE评分的影响。
共有112例患者（男性28例，女性84例）纳入分析。患者年龄范围为66至94岁（中位数：83岁）。MMSE评分范围为6至30分（中位数：24分）。57例患者（50.9%）检测到ACES囊肿。有和没有ACES囊肿的患者年龄无显著差异（P = 0.058）。与没有ACES囊肿的患者相比，有ACES囊肿的患者MMSE评分显著更低（P < 0.001）。在有ACES囊肿的患者中，年龄与MMSE评分无显著相关性（ρ = -0.178，P = 0.185），而在没有ACES囊肿的患者中观察到显著的负相关（ρ = -0.347，P = 0.001）。ACES囊肿的存在被确定为MMSE评分较低的独立预测因素（比值比 = 15.2，95%置信区间 = 5.59 - 41.4，P < 0.001）。
ACES囊肿的存在与较低的MMSE评分显著相关。ACES囊肿可能参与了影响认知功能的病理过程。
