迟做总比不做好：成人急性淋巴细胞白血病诱导治疗期间延迟使用天冬酰胺酶。
Better late than never: Delayed asparaginase during induction for acute lymphoblastic leukaemia in adults.
作者信息
Valtis Yannis K, Luskin Marlise R
机构信息
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Division of Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
出版信息
Br J Haematol. 2025 Mar;206(3):1016-1017. doi: 10.1111/bjh.19928. Epub 2024 Nov 24.
Paediatric regimens which incorporate asparaginase have improved outcomes of adolescents and younger adults with acute lymphoblastic leukaemia but are limited by toxicity. This retrospective report by Tinajero and Xu suggests that delaying the timing of asparaginase administration during ALL induction may reduce risk of hepatotoxicity. Commentary on: Tinajero et al. Delaying pegaspargase during induction in adults with acute lymphoblastic leukaemia is associated with lower risk of high-grade hepatotoxicity without adversely impacting outcomes. Br J Haematol 2025; 206:868-875.
包含天冬酰胺酶的儿科治疗方案改善了青少年和年轻成人急性淋巴细胞白血病的治疗结果，但受到毒性的限制。蒂纳杰罗和徐的这份回顾性报告表明，在急性淋巴细胞白血病诱导治疗期间推迟天冬酰胺酶给药时间可能会降低肝毒性风险。评论：蒂纳杰罗等人。在成人急性淋巴细胞白血病诱导治疗期间推迟聚乙二醇化天冬酰胺酶给药与高级别肝毒性风险较低相关，且对治疗结果无不利影响。《英国血液学杂志》2025年；206:868 - 875。
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