Van Eden C G
J Comp Neurol. 1986 Feb 15;244(3):349-59. doi: 10.1002/cne.902440307.
The postnatal ingrowth of thalamocortical fibers from the mediodorsal nucleus to the prefrontal cortex was investigated in relation to the development of cortical lamination. Like the dopaminergic fibers in the prefrontal cortex and the thalamic fibers in the visual cortex, the mediodorsal fibers have entered the prefrontal cortex at birth. Most of the fibers are found in the developing layer VI, but, in contrast to the above-mentioned systems, a considerable number of mediodorsal fibers have already penetrated into the upper, most immature part of the cortical plate on postnatal day 1. From day 1 to day 7 an increasing number of mediodorsal fibers reach the upper cortical plate, which by then is developing layer III, the terminal layer of these fibers. The reciprocal connection from the layer VI cells of the prefrontal cortex to the mediodorsal nucleus develops between day 4 and day 9. Finally, the projection from the contralateral prefrontal cortex to the mediodorsal nucleus is established around day 10. The early presence of the mediodorsal fibers in the upper, differentiating cortical plate might indicate an important role for the mediodorsal fibers in the laminar development of the prefrontal cortex.
研究了从背内侧核到前额叶皮质的丘脑皮质纤维的产后长入与皮质分层发育的关系。与前额叶皮质中的多巴胺能纤维和视觉皮质中的丘脑纤维一样，背内侧纤维在出生时就已进入前额叶皮质。大多数纤维位于发育中的VI层，但与上述系统不同的是，相当数量的背内侧纤维在出生后第1天就已穿透到皮质板最上部、最不成熟的部分。从第1天到第7天，越来越多的背内侧纤维到达上部皮质板，此时该皮质板正在发育为III层，即这些纤维的终末层。前额叶皮质VI层细胞与背内侧核之间的相互连接在第4天到第9天之间形成。最后，对侧前额叶皮质到背内侧核的投射在第10天左右建立。背内侧纤维在前部正在分化的皮质板中的早期存在可能表明背内侧纤维在前额叶皮质分层发育中起重要作用。
