Huntley A C
J Am Acad Dermatol. 1986 Apr;14(4):612-7. doi: 10.1016/s0190-9622(86)70078-9.
Several authors have now described the relatively common occurrence of thickening of the skin on the dorsum of the fingers and hands in persons with diabetes mellitus, and skin thickening in these patients has been documented histologically for other body locations. To date, the presence of finger and hand skin thickening has been determined by an examination difficult to objectify--palpation and attempted tenting of the affected area. In a survey of sixty subjects with diabetes, it was found that forty-five patients (75%) have a visual marker for skin thickening, that is, a pebbly appearance of the knuckle and distal finger skin. Similar changes were present in eleven of control subjects (21%). A limited histologic study indicates that the epidermis and papillary dermis are primarily responsible for this thickening. A pebbly appearance of volar finger skin may be a more easily recognized marker of diabetic skin thickening.
现在已有多位作者描述了糖尿病患者手指和手背皮肤增厚这一相对常见的现象，并且这些患者身体其他部位的皮肤增厚也已得到组织学证实。迄今为止，手指和手部皮肤增厚的情况是通过一种难以客观化的检查来确定的——对患区进行触诊并试图使其形成帐篷状。在一项对60名糖尿病患者的调查中发现，45名患者（75%）有皮肤增厚的视觉标志，即指关节和手指远端皮肤呈卵石样外观。11名对照受试者（21%）也有类似变化。一项有限的组织学研究表明，表皮和乳头层真皮是这种增厚的主要原因。手掌手指皮肤的卵石样外观可能是糖尿病皮肤增厚更容易识别的标志。
