Nantong Center for Disease Control and Prevention, Nantong, Jiangsu, China.
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
Front Public Health. 2024 Nov 8;12:1494511. doi: 10.3389/fpubh.2024.1494511. eCollection 2024.
To describe antibiotic exposure in children and explore its association with overweight/obesity.
In June 2022, 328 kindergarten and primary school children were selected from Nantong city in Jiangsu Province. Questionnaires were distributed, and morning urine samples were obtained. Total urinary concentrations of 41 antibiotics were measured using ultra-performance liquid chromatography and tandem mass spectrometry. The rates of antibiotic exposure were expressed as percentages (%), specific percentiles ( and ), and the maximum values were used to describe the concentration of antibiotics. The association between urinary antibiotic creatinine-adjusted and overweight/obesity was analyzed using logistic regression.
A total of 328 children were initially recruited, of which 295 aged 3-8 years met the inclusion criteria and were finally included in the study. The biomonitoring results revealed that 35 antibiotics were detected, with a total detection frequency of 98.31%. Among the included children, 24.75% were classified as overweight/obesity. Multinomial logistic regression analyses revealed significant associations between overweight/obese and exposure to veterinary antibiotics (VAs) and preferred veterinary antibiotics (PVAs). After adjusting for various overweight/obesity-relevant variables, higher exposure to sulfamethoxazole [OR = 2.35, 95% confidence interval (CI):1.17-4.70], norfloxacin (OR = 2.66, 95% CI: 1.01-7.08), and fluoroquinolones (OR = 1.97, 95% CI: 1.02-3.78) were significantly associated with overweight/obesity ( < 0.05). In addition, after stratification by sex and adjustment for confounding variables, sex-specific differences were observed in the association between antibiotic exposure and overweight/obesity. Notably, these associations were predominantly observed among boys.
Children were extensively exposed to antibiotics. Exposure to certain types of veterinary antibiotics and preferred veterinary antibiotic exposure, mainly through food or drinking water, are associated with an increased risk of overweight/obesity in children.
描述儿童抗生素暴露情况，并探讨其与超重/肥胖的关系。
2022 年 6 月，从江苏省南通市选取 328 名幼儿园和小学生。发放问卷，并采集晨尿样本。采用超高效液相色谱-串联质谱法测定 41 种抗生素的总尿浓度。抗生素暴露率用百分数（%）、特定百分位数（ 和 ）和抗生素浓度的最大值表示。采用 logistic 回归分析抗生素尿肌酐校正后与超重/肥胖的关系。
共纳入 328 名儿童，其中 295 名 3-8 岁儿童符合纳入标准，最终纳入 295 名儿童进行研究。生物监测结果显示，检测到 35 种抗生素，总检出率为 98.31%。在纳入的儿童中，24.75%超重/肥胖。多分类 logistic 回归分析显示，超重/肥胖与兽用抗生素（VAs）和首选兽用抗生素（PVAs）暴露显著相关。在调整各种与超重/肥胖相关的变量后，磺胺甲恶唑[OR=2.35，95%可信区间（CI）：1.17-4.70]、诺氟沙星（OR=2.66，95% CI：1.01-7.08）和氟喹诺酮类药物（OR=1.97，95% CI：1.02-3.78）的高暴露与超重/肥胖显著相关（<0.05）。此外，按性别分层并调整混杂因素后，发现抗生素暴露与超重/肥胖之间存在性别特异性差异。值得注意的是，这些关联主要发生在男孩中。
儿童广泛接触抗生素。通过食物或饮用水摄入某些类型的兽用抗生素和首选兽用抗生素与儿童超重/肥胖的风险增加有关。
