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放疗后患者的乳房切除术后乳房重建:对腹壁下深动脉穿支皮瓣和背阔肌皮瓣结局的12年随访

Postmastectomy Breast Reconstruction in Irradiated Patients: A 12-year follow-up of Deep Inferior Epigastric Perforator and Latissimus Dorsi Flap Outcomes.

作者信息

Edsander-Nord Åsa, Assareh Armin, Halle Martin, Skogh Ann-Charlott Docherty

机构信息

Department of Plastic surgery and Craniofacial surgery, Karolinska University hospital, Stockholm, Sweden.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

出版信息

JPRAS Open. 2024 Oct 18;42:361-369. doi: 10.1016/j.jpra.2024.10.008. eCollection 2024 Dec.

Abstract

The aim of the current study was to conduct a 12-year follow-up on the authors´ previously evaluated group of irradiated patients who underwent postmastectomy breast reconstruction with deep inferior epigastric perforator (DIEP) and latissimus dorsi (LD)-flaps with implant. The follow-up involved 67% of the patients from the original cohort (17 DIEP and 13 LD). Patient-reported outcome measures (PROMS) were measured using the BREAST-Q, SF-36, a satisfaction form, and Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaires. Aesthetics were evaluated by a board of independent plastic surgeons. The average follow-up time was 12.6 years (DIEP) and 11.8 years (LD). Contralateral symmetry procedures were performed on 15 DIEP and 9 LD patients. Both groups underwent an average of 2.5 reconstructive procedures. The BREAST-Q and satisfaction questionnaires showed no group difference. SF-36 showed no group difference but had significantly higher values in both groups compared to the general population with regard to the physical role limitations (p=0.034 and p=0.004, respectively). The DASH scores showed minimal shoulder function impact in the LD group. Aesthetic evaluations revealed a discrepancy between the opinions of the patients and surgeons, with patients valuing the size (p=0.015) and overall aesthetic (p=0.012) of the reconstructed breast higher in the DIEP group. The weighted kappa analysis showed poor agreement between patients and surgeons. Over time, the patients´ preferences shifted from LD to DIEP flaps, possibly due to the more natural aging process associated with autologous reconstruction. This underscores the importance of long term follow-up studies.

摘要

本研究的目的是对作者之前评估的一组接受乳房切除术后乳房重建的放疗患者进行为期12年的随访,这些患者采用了腹壁下深动脉穿支(DIEP)皮瓣和背阔肌(LD)肌皮瓣联合植入物进行重建。随访对象为原队列中67%的患者(17例DIEP皮瓣和13例LD肌皮瓣)。使用BREAST-Q、SF-36、一份满意度问卷以及上肢、肩部和手部功能障碍(DASH)问卷来测量患者报告的结局指标(PROMS)。由独立的整形外科医生委员会对美学效果进行评估。平均随访时间为12.6年(DIEP皮瓣组)和11.8年(LD肌皮瓣组)。15例DIEP皮瓣患者和9例LD肌皮瓣患者进行了对侧对称手术。两组平均都接受了2.5次重建手术。BREAST-Q问卷和满意度问卷显示两组之间没有差异。SF-36问卷显示两组之间没有差异,但在身体角色限制方面,两组的值均显著高于一般人群(分别为p = 0.034和p = 0.004)。DASH评分显示LD肌皮瓣组对肩部功能的影响最小。美学评估显示患者和外科医生的意见存在差异,DIEP皮瓣组患者对重建乳房的大小(p = 0.015)和整体美学效果(p = 0.012)评价更高。加权kappa分析显示患者和外科医生之间的一致性较差。随着时间的推移,患者的偏好从LD肌皮瓣转向了DIEP皮瓣,这可能是由于自体重建相关的自然衰老过程更为明显。这突出了长期随访研究的重要性。

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