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两亲性 Janus 纳米粒子通过减弱炎症和靶向杀菌能力有效治疗细菌性肺炎。

Amphiphilic Janus Nanoparticles for Effective Treatment of Bacterial Pneumonia by Attenuating Inflammation and Targeted Bactericidal Capability.

机构信息

School of Pharmacy, Shandong Engineering Research Center of New-Type Drug Loading & Releasing Technology and Preparation, Binzhou Medical University, Yantai, Shandong, People's Republic of China.

出版信息

Int J Nanomedicine. 2024 Nov 18;19:12039-12051. doi: 10.2147/IJN.S486450. eCollection 2024.

DOI:10.2147/IJN.S486450
PMID:39583317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11583765/
Abstract

INTRODUCTION

-induced pneumonia is marked by considerable infiltration of inflammatory cells and biofilm formation, which causes acute and transient lung inflammation and infection. Nevertheless, the discovery of alternative preventative and therapeutic methods is essential due to the high mortality rates in clinical settings and the resistance of infection to multiple medications.

PURPOSE

In this research, we constructed amphiphilic Janus nanoparticles (JNPs, denoted as SSK1@PDA/CaP@CIP), loaded with hydrophobic SSK1, a β-galactosidase (β-gal)-activated prodrug for reducing macrophages, and hydrophilic ciprofloxacin (CIP), a classic antibiotic for treating infection. SSK1@PDA/CaP@CIP was designed to effectively attenuate inflammation, eradicate biofilms, and combat planktonic .

RESULTS

As expected, SSK1@PDA/CaP@CIP was able to target the infection site and demonstrated outstanding efficacy in treating strain PAO1-induced pneumonia by regulating macrophage infiltration to reduce inflammation and removing planktonic bacteria and biofilms to control infection. Additionally, the primary organs did not exhibit any discernible pathological changes following treatment with SSK1@PDA/CaP@CIP, which indicates superior biocompatibility throughout the treatment course.

DISCUSSION

In conclusion, our investigation introduced a promising approach to the treatment of pneumonia associated with PAO1.

摘要

简介

  • 诱导的肺炎以大量炎症细胞浸润和生物膜形成为特征，导致急性和短暂的肺部炎症和感染。然而，由于临床环境中的高死亡率和 感染对多种药物的耐药性，发现替代的预防和治疗方法至关重要。

目的

在这项研究中，我们构建了两亲性 Janus 纳米粒子（JNPs，记为 SSK1@PDA/CaP@CIP），负载疏水性 SSK1，这是一种β-半乳糖苷酶（β-gal）激活的前药，用于减少巨噬细胞，以及亲水性环丙沙星（CIP），这是一种治疗感染的经典抗生素。SSK1@PDA/CaP@CIP 的设计目的是有效减轻炎症，根除生物膜，并对抗浮游 。

结果

正如预期的那样，SSK1@PDA/CaP@CIP 能够靶向感染部位，并通过调节巨噬细胞浸润来减少炎症，去除浮游细菌和生物膜来控制感染，从而在治疗 PAO1 诱导的肺炎方面表现出出色的疗效。此外，用 SSK1@PDA/CaP@CIP 治疗后，主要器官没有显示出任何明显的病理变化，这表明在整个治疗过程中具有优异的生物相容性。

讨论

总之，我们的研究介绍了一种有前途的治疗与 PAO1 相关的肺炎的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/8f13d31db01b/IJN-19-12039-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/53c12d76f276/IJN-19-12039-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/eec068586b67/IJN-19-12039-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/dd806c6f7284/IJN-19-12039-g0003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/126f1e4228d7/IJN-19-12039-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/189b47290698/IJN-19-12039-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/8f13d31db01b/IJN-19-12039-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/53c12d76f276/IJN-19-12039-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/eec068586b67/IJN-19-12039-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/dd806c6f7284/IJN-19-12039-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/ac052d0af4dc/IJN-19-12039-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/126f1e4228d7/IJN-19-12039-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/189b47290698/IJN-19-12039-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38f/11583765/8f13d31db01b/IJN-19-12039-g0007.jpg

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