Kalantzi Sofia, Alexakis Chalent, Anagnostaki Maria Emmanouela, Anagnostaki Ismini, Zacharis Konstantinos
Department of Obstetrics and Gynecology, General Hospital of Lamia, Lamia, GRC.
Department of Dermatology, Papageorgiou General Hospital, Thessaloniki, GRC.
Cureus. 2024 Oct 24;16(10):e72290. doi: 10.7759/cureus.72290. eCollection 2024 Oct.
Herpes zoster (HZ), caused by the reactivation of the varicella-zoster virus (VZV), typically presents as a unilateral vesicular rash in a dermatomal pattern. Its occurrence in the genital area is rare and often misdiagnosed. We report the case of a 51-year-old woman who presented with sudden vulvar pain and burning, without a history of immunodeficiency or sexually transmitted infections. Examination revealed unilateral vesicular lesions on the left labium majus, perianal area, medial thigh, and gluteal region along the second sacral (S2) and third sacral (S3) dermatomes. Polymerase chain reaction (PCR) confirmed VZV and ruled out herpes simplex virus (HSV). The patient was treated with brivudine, mupirocin, and analgesics, resulting in a complete resolution of symptoms. This case highlights the need to consider HZ in the differential diagnosis of genital lesions. Early recognition and treatment of atypical presentations can prevent complications and improve patient outcomes.
带状疱疹（HZ）由水痘-带状疱疹病毒（VZV）再激活引起，通常表现为沿皮节分布的单侧水疱性皮疹。其在生殖器部位的发生较为罕见，且常被误诊。我们报告一例51岁女性病例，该患者出现突发的外阴疼痛和烧灼感，无免疫缺陷或性传播感染病史。检查发现沿第二骶神经（S2）和第三骶神经（S3）皮节在左侧大阴唇、肛周区域、大腿内侧和臀区有单侧水疱性病变。聚合酶链反应（PCR）证实为VZV感染，并排除了单纯疱疹病毒（HSV）感染。患者接受了溴夫定、莫匹罗星和镇痛药治疗，症状完全缓解。该病例强调了在生殖器病变的鉴别诊断中需考虑HZ的必要性。对非典型表现的早期识别和治疗可预防并发症并改善患者预后。
