Supawat Araya, Palachai Nut, Jittiwat Jinatta
Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand.
Biomed Rep. 2024 Nov 11;22(1):10. doi: 10.3892/br.2024.1888. eCollection 2025 Jan.
Focal ischemia occurs when a cerebral artery becomes obstructed by an embolus or thrombus, leading to a rapid reduction in cerebral blood flow and significantly increasing the risk of mortality and disability. This condition is of particular concern in developing countries, where its prevalence is on the rise. Galangin, a flavonoid found in , shows strong antioxidant, anti-inflammatory and anti-apoptotic properties. Its wide-ranging bioactivity in both and animal studies points to promising therapeutic applications. Given the role of oxidative stress in the pathophysiology of focal ischemia, the present study explored the effects of galangin on oxidative stress markers and antioxidant defenses in an animal model of the disease. A total of 60 healthy male Wistar rats were randomly assigned to six groups: Control, right middle cerebral artery occlusion (Rt.MCAO) + vehicle, Rt.MCAO + piracetam, and Rt.MCAO + galangin at doses of 25, 50 and 100 mg/kg body weight. The results indicated that 7 days of galangin treatment reduces infarct volume, malondialdehyde levels, and the density ratio of mitogen-activated protein kinase, while enhancing catalase, glutathione peroxidase and superoxide dismutase activities, and improving the density ratio of mitofusin 2 protein in the cortex and hippocampus. In conclusion, galangin showed significant potential in mitigating the pathological changes caused by cerebral ischemia, likely due to its antioxidant properties and modulation of mitochondrial dynamics. Additional research is now needed to explore the biochemical and neurological impacts of galangin in focal cerebral ischemia and to fully elucidate its mechanism of action.
当脑动脉被栓子或血栓阻塞时，就会发生局灶性缺血，导致脑血流量迅速减少，并显著增加死亡和残疾风险。这种情况在发展中国家尤为令人担忧，其患病率正在上升。高良姜素是一种存在于[具体来源未提及]中的黄酮类化合物，具有很强的抗氧化、抗炎和抗凋亡特性。其在[具体研究对象未提及]和动物研究中的广泛生物活性表明其具有广阔的治疗应用前景。鉴于氧化应激在局灶性缺血病理生理学中的作用，本研究探讨了高良姜素对该疾病动物模型中氧化应激标志物和抗氧化防御的影响。总共60只健康雄性Wistar大鼠被随机分为六组：对照组、右侧大脑中动脉闭塞（Rt.MCAO）+赋形剂组、Rt.MCAO+吡拉西坦组以及Rt.MCAO+高良姜素组，高良姜素组的剂量分别为25、50和100mg/kg体重。结果表明，高良姜素治疗7天可减少梗死体积、丙二醛水平以及丝裂原活化蛋白激酶的密度比，同时增强过氧化氢酶、谷胱甘肽过氧化物酶和超氧化物歧化酶的活性，并改善皮质和海马体中丝裂融合蛋白2的密度比。总之，高良姜素在减轻脑缺血引起的病理变化方面显示出显著潜力，这可能归因于其抗氧化特性和对线粒体动力学的调节作用。现在需要进一步研究来探索高良姜素对局灶性脑缺血的生化和神经学影响，并充分阐明其作用机制。
