Marques Luisa, de Sousa Catarina, Pinto Fausto J, Caldeira Daniel
Faculdade de Medicina, Universidade de Lisboa, Portugal.
Cardiology Department, Hospital Universitário de Santa Maria - ULS Santa Maria (ULSSM), CAML, Portugal.
Heliyon. 2024 Nov 4;10(21):e39893. doi: 10.1016/j.heliyon.2024.e39893. eCollection 2024 Nov 15.
Infective endocarditis (IE) is a serious heart valvular condition. While mitral valve prolapse (MVP) has been associated with an increased risk of IE, the magnitude of this association remains poorly quantified. This systematic review aimed to better estimate the risk of developing IE among MVP patients compared with the general population.
MEDLINE, Cochrane Library (CENTRAL) and Web of Science databases were searched electronically to find all the relevant cohort and case-control studies. Pooled estimates of odds ratios (ORs) and 95 % confidence intervals (CIs) were derived by random effects meta-analysis. Heterogeneity was assessed using the I2 test.
A total of six studies were considered eligible, and the obtained results showed that MVP patients had a higher risk of IE when compared to the general population (OR 7.83, 95 % CI 5.11, 12.02; I2 = 0 %). Posterior analysis according to the risk of bias and study design didn't show any significant variations in the direction and magnitude of the effect.
The magnitude of increased risk of IE of 7-fold warrants further attention for patients with MVP. Further contemporary studies and prophylaxis studies should be considered.
感染性心内膜炎（IE）是一种严重的心脏瓣膜疾病。虽然二尖瓣脱垂（MVP）与IE风险增加有关，但这种关联的程度仍未得到充分量化。本系统评价旨在更好地估计与普通人群相比，MVP患者发生IE的风险。
通过电子检索MEDLINE、Cochrane图书馆（CENTRAL）和科学网数据库，以查找所有相关的队列研究和病例对照研究。采用随机效应荟萃分析得出比值比（OR）和95%置信区间（CI）的合并估计值。使用I2检验评估异质性。
共六项研究被认为符合条件，所得结果显示，与普通人群相比，MVP患者发生IE的风险更高（OR 7.83，95%CI 5.11，12.02；I2 = 0%）。根据偏倚风险和研究设计进行的事后分析未显示效应方向和大小有任何显著差异。
MVP患者IE风险增加7倍的程度值得进一步关注。应考虑开展进一步的当代研究和预防研究。
