N'do Jotham Yhi-Pênê, Paré Dramane, Bondé Loyapin, Hilou Adama
Laboratory of Applied Biochemistry and Chemistry, Joseph Ki-Zerbo University, 03 BP 7021, Ouagadougou, 03, Burkina Faso.
Laboratory of Plant Biology and Ecology, University Joseph Ki-Zerbo, 03 BP 7021, Ouagadougou, 03, Burkina Faso, Burkina Faso.
Heliyon. 2024 Nov 6;10(21):e40159. doi: 10.1016/j.heliyon.2024.e40159. eCollection 2024 Nov 15.
Medicinal plants can help combat antibiotic resistance by providing novel, active molecules. Three plant species of the genus are widely used in traditional medicine in the Mouhoun region for the treatment of cutaneous and respiratory diseases. Therefore, it is important to determine the ethnopharmacological potential of bark extracts from the trunks of these three species.
This study compared the phytochemical and biological activities of extracts from three species to determine their ethnopharmacology.
The medicinal properties of the extracts were assessed based on their ability to inhibit the growth of the following microorganisms: , , sa, , , and . The significant interest in these medicinal plants among the local communities were elucidated by their antioxidant properties and phytochemical composition, along with the detection key bioactive compounds. Major phytochemical groups and phenolic compounds were determined using high-performance liquid chromatography with a diode array detector. These phytochemical findings were validated by evaluating the antioxidant capacity of the extracts using DPPH, FRAP, and ABTS assays.
Hydroethanolic, ethanolic, and hexane extracts from the bark of three species inhibited the growth of both bacteria and fungi, as evidenced by their minimum inhibitory concentrations (MICs).The findings showed that species were most effective against various tested bacteria and fungi, with MICs ranging from 0.1 to 6.25 mg/mL. , and extracts demonstrated 50 % inhibition of DPPH at concentrations ranging from 0.04 to 0.6 mg/mL. Phytochemical analysis revealed the presence of several families of chemical compounds, such as total phenolics and flavonoids. Phenolic compounds identified by HPLC in ethanolic extracts of , such as isorhamnetin, quercetin, and ferulic acid, are recognised for their antimicrobial and antioxidant properties.
These findings establish an ethnobotany for these three species, with their chromatographic characteristics facilitating the identification of key molecules of interest. The ethanolic extract of can be used in phytomedicinal formulations against bacterial ( and ) and fungal ( and ) infections, both of which are recurrently recorded in certain skin and respiratory tract diseases.
药用植物可通过提供新型活性分子来帮助对抗抗生素耐药性。该属的三种植物在穆洪地区的传统医学中被广泛用于治疗皮肤和呼吸道疾病。因此，确定这三种植物树干树皮提取物的民族药理学潜力很重要。
本研究比较了三种植物提取物的植物化学和生物学活性，以确定它们的民族药理学特性。
基于提取物抑制以下微生物生长的能力来评估其药用特性：[此处原文微生物名称缺失]、[此处原文微生物名称缺失]、金黄色葡萄球菌、[此处原文微生物名称缺失]、[此处原文微生物名称缺失]、[此处原文微生物名称缺失]和[此处原文微生物名称缺失]。通过其抗氧化特性、植物化学组成以及检测关键生物活性化合物，阐明了当地社区对这些药用植物的浓厚兴趣。使用配备二极管阵列检测器的高效液相色谱法测定主要植物化学基团和酚类化合物。通过使用DPPH、FRAP和ABTS测定法评估提取物的抗氧化能力，验证了这些植物化学研究结果。
三种植物树皮的水乙醇提取物、乙醇提取物和己烷提取物均抑制细菌和真菌的生长，其最低抑菌浓度（MIC）证明了这一点。研究结果表明，[此处原文植物名称缺失]对各种测试细菌和真菌最有效，MIC范围为0.1至6.25毫克/毫升。[此处原文植物名称缺失]、[此处原文植物名称缺失]和[此处原文植物名称缺失]提取物在浓度为0.04至0.6毫克/毫升时对DPPH表现出50%的抑制作用。植物化学分析表明存在几类化合物，如总酚和黄酮类化合物。通过HPLC在[此处原文植物名称缺失]乙醇提取物中鉴定出的酚类化合物，如异鼠李素、槲皮素和阿魏酸，因其抗菌和抗氧化特性而闻名。
这些研究结果确立了这三种植物的民族植物学，其色谱特征有助于鉴定关键的目标分子。[此处原文植物名称缺失]的乙醇提取物可用于植物药用制剂，以对抗细菌（[此处原文细菌名称缺失]和[此处原文细菌名称缺失]）和真菌（[此处原文真菌名称缺失]和[此处原文真菌名称缺失]）感染，这两种感染在某些皮肤和呼吸道疾病中经常出现。
