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自身免疫性疾病的现代流行病。

The Modern Epidemic of Autoimmunity.

机构信息

Division of Rheumatology & Immunology, Department of Internal Medicine, Tainan Municipal Hospital, Tainan, Taiwan.

Department of Orthopedics, Feng Yuan Hospital, Ministry of Health and Welfare, Taichung, Taiwan.

出版信息

Int J Rheum Dis. 2024 Nov;27(11):e15426. doi: 10.1111/1756-185X.15426.

Abstract

Autoimmunity occurs when the immune system mistakenly attacks the body, but the presence of autoantibodies, such as antinuclear antibodies (ANAs), does not always lead to autoimmune diseases. Globally, autoimmunity is on the rise, influenced by socioeconomic factors, environmental exposure, diet, and stress. Climate change and pollution further exacerbate risks. The COVID-19 pandemic has worsened the issue, with unvaccinated individuals showing higher rates of autoimmune conditions postinfection. Preventive strategies, including healthy diets, stress management, and vaccination, are crucial in combating this growing epidemic. Collaboration between individuals, healthcare providers, and policymakers is critical to mitigate the rise in autoimmune disorders and enhance public health.

摘要

自身免疫是指免疫系统错误攻击身体,但自身抗体(如抗核抗体)的存在并不总是导致自身免疫性疾病。在全球范围内,自身免疫性疾病呈上升趋势,受到社会经济因素、环境暴露、饮食和压力的影响。气候变化和污染进一步加剧了风险。COVID-19 大流行使情况恶化,未接种疫苗的个体在感染后出现自身免疫状况的比例更高。包括健康饮食、压力管理和接种疫苗在内的预防策略对于应对这一日益严重的流行病至关重要。个人、医疗保健提供者和政策制定者之间的合作对于减轻自身免疫性疾病的上升和改善公共健康至关重要。

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