Iravani-Naeeni Ardavan, Mohagheghi Amir
Centre for Cognitive and Clinical Neuroscience, College of Health, Medicine and Life Sciences, Brunel University London, London UB8 3PH, UK.
J Funct Morphol Kinesiol. 2024 Oct 25;9(4):206. doi: 10.3390/jfmk9040206.
Parkinson's Disease (PD) can be associated with balance and gait impairments leading to increased risk of falls. Several studies have reported positive effects of various forms of vestibular stimulation (VS) for improving balance and stability in people with PD (PwP). The purpose of present study was to synthesise the current evidence on the effectiveness of VS, highlighting its potential benefits in improving postural stability and reducing gait impairments in people with Parkinson's Disease. A systematic search was conducted across databases Cochrane, Medline, PEDro, PubMed, Web of Science, and Google Scholar. Studies were included if they involved PwP at stages 3 or 4 of the Hoehn and Yahr scale, aged 60 years or older. The Risk of Bias (RoB) was assessed using the ROBINS-I tool. The review followed the PRISMA guidelines and the protocol was registered with PROSPERO (CRD42022283898). demonstrated that various forms of VS have shown promise in mitigating symptoms of vestibular dysfunction and improving gait and balance in PwP. However, the overall RoB ranged from moderate to critical, with variations across different domains. While VS appears to offer potential benefits in improving balance and gait in PwP, the presence of biases in the reviewed studies necessitate caution in interpreting the results. Further research should focus on addressing these biases to confirm the therapeutic potential of VS in PD.
帕金森病（PD）可能与平衡和步态障碍相关，从而导致跌倒风险增加。多项研究报告了各种形式的前庭刺激（VS）对改善帕金森病患者（PwP）平衡和稳定性的积极作用。本研究的目的是综合当前关于VS有效性的证据，突出其在改善帕金森病患者姿势稳定性和减少步态障碍方面的潜在益处。我们在Cochrane、Medline、PEDro、PubMed、科学网和谷歌学术等数据库中进行了系统检索。纳入的研究需涉及处于Hoehn和Yahr量表3或4期、年龄在60岁及以上的帕金森病患者。使用ROBINS - I工具评估偏倚风险（RoB）。本综述遵循PRISMA指南，研究方案已在PROSPERO（CRD42022283898）注册。结果表明，各种形式的VS在减轻帕金森病患者前庭功能障碍症状以及改善步态和平衡方面显示出前景。然而，总体RoB从中度到严重不等，不同领域存在差异。虽然VS似乎在改善帕金森病患者平衡和步态方面具有潜在益处，但所审查研究中存在的偏倚使得在解释结果时需要谨慎。进一步的研究应侧重于解决这些偏倚，以确认VS在帕金森病中的治疗潜力。
