Mera Azaín Cristian Alejandro, Vargas Pasquel Johan Leandro, Quijano Gómez Sandra Milena, Rodríguez-Pardo Viviana Marcela
Grupo Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá 110111, Colombia.
Hematol Rep. 2024 Nov 23;16(4):732-741. doi: 10.3390/hematolrep16040070.
Multiple myeloma (MM) is a malignant plasma cell disorder characterized by the accumulation of abnormal plasma cells in the bone marrow. Mesenchymal stem cells (MSCs) and reticulated platelets (RPs) have been implicated in the pathogenesis of MM. This narrative review aims to explore the role of MSCs and RPs in the pathophysiology of MM, particularly their clinical use as possible variables of prognostic value in this hematologic neoplasia. The interaction between MSCs and MM cells within the bone marrow microenvironment supports MM cell survival, proliferation, and drug resistance. MSCs contribute to the development and maintenance of MM through the secretion of various factors, including cytokines, chemokines, and growth factors. Moreover, RPs, young and highly reactive platelets, have been implicated in promoting angiogenesis, tumor growth, and metastasis in MM. Several studies show that cells such as MSCs and platelets participate actively in the biology of the disease. Still, in clinical practice, they are not considered part of evaluating affected patients. In this review, we explore the possibility of including the evaluation of MSCs and PRs in the clinical practice for patients with MM as part of the strategies to improve the outcomes of this disease.
多发性骨髓瘤（MM）是一种恶性浆细胞疾病，其特征是骨髓中异常浆细胞积聚。间充质干细胞（MSCs）和网状血小板（RPs）与MM的发病机制有关。这篇叙述性综述旨在探讨MSCs和RPs在MM病理生理学中的作用，特别是它们作为这种血液系统肿瘤中可能具有预后价值的变量的临床应用。骨髓微环境中MSCs与MM细胞之间的相互作用支持MM细胞的存活、增殖和耐药性。MSCs通过分泌多种因子，包括细胞因子、趋化因子和生长因子，促进MM的发生和维持。此外，RPs，即年轻且反应性高的血小板，与MM中的血管生成、肿瘤生长和转移有关。多项研究表明，MSCs和血小板等细胞积极参与该疾病的生物学过程。然而，在临床实践中，它们并未被视为评估受影响患者的一部分。在本综述中，我们探讨了将MSCs和PRs的评估纳入MM患者临床实践的可能性，作为改善该疾病治疗结果策略的一部分。
