Bito Tomohiro
Department of Agricultural, Life, and Environmental Sciences, Faculty of Agriculture, Tottori University, Tottori, Japan.
Biosci Biotechnol Biochem. 2025 Feb 20;89(3):338-341. doi: 10.1093/bbb/zbae169.
Vitamin B12 (B12) is a water-soluble substance that is a member of the B-vitamin family. Its recommended daily dose in adult men and women is 2.4 µg, which is the lowest among the 13 vitamins. B12 deficiency causes megaloblastic anemia and neurological disorders. It is also associated with cognitive decline, growth retardation, infertility, and other symptoms. Nevertheless, the detailed mechanisms of which remain unclear. Caenorhabditis elegans is a small organism, with a length of approximately 1 mm and a lifespan of approximately 3 weeks. It has similar fundamental biological structures, such as the muscles, nervous system, and digestive tract, with mammals. Previous studies have shown that B12 is required for the normal development of C. elegans, similar to that of mammals. The current study aimed to perform a detailed investigation of the mechanisms underlying the development of B12 deficiency using a dietary B12-deficient C. elegans model.
维生素B12（B12）是一种水溶性物质，属于B族维生素家族。成年男性和女性的每日推荐剂量为2.4微克，这是13种维生素中最低的。B12缺乏会导致巨幼细胞贫血和神经紊乱。它还与认知能力下降、生长发育迟缓、不孕不育及其他症状有关。然而，其具体机制仍不清楚。秀丽隐杆线虫是一种小型生物，体长约1毫米，寿命约3周。它与哺乳动物具有相似的基本生物结构，如肌肉、神经系统和消化道。先前的研究表明，与哺乳动物一样，B12是秀丽隐杆线虫正常发育所必需的。当前的研究旨在利用饮食中缺乏B12的秀丽隐杆线虫模型，对B12缺乏导致发育问题的潜在机制进行详细研究。
