Anhui Institute of Pediatric Research, Anhui Provincial Children's Hospital (Children's Hospital of Fudan University Anhui Hospital; Children's Medical Center of Anhui Medical University), Hefei, Anhui, China.
Department of Scientific Research and Education, Anhui Provincial Children's Hospital (Children's Hospital of Fudan University Anhui Hospital; Children's Medical Center of Anhui Medical University), Hefei, Anhui, China.
Ren Fail. 2024 Dec;46(2):2433160. doi: 10.1080/0886022X.2024.2433160. Epub 2024 Nov 25.
Acute kidney injury (AKI) is a common and severe clinical disorder in which endoplasmic reticulum (ER) stress plays an important regulatory role. In this review, we summarize the research progress on the relationship between ER stress and AKI. It emphasizes the importance of maintaining a balance between promoting and protecting ER stress during AKI and highlights the potential of ER stress-targeted drugs as a new therapeutic approach for AKI. The article also discusses the need for developing drugs that target ER stress effectively while avoiding adverse effects on normal cells and tissues. The review concludes that with a more comprehensive understanding of ER stress mechanisms and advancements in research techniques, more effective treatment options for AKI can be developed in the future.
急性肾损伤（AKI）是一种常见且严重的临床疾病，其中内质网（ER）应激起着重要的调节作用。在这篇综述中，我们总结了 ER 应激与 AKI 之间关系的研究进展。它强调了在 AKI 期间维持 ER 应激促进和保护之间平衡的重要性，并突出了 ER 应激靶向药物作为 AKI 新治疗方法的潜力。文章还讨论了需要开发有效靶向 ER 应激的药物，同时避免对正常细胞和组织产生不良反应。综述结论认为，随着对内质网应激机制的更全面理解和研究技术的进步，未来可以开发出更有效的 AKI 治疗选择。
