Aix Marseille Univ, AP-HM, Department of Urology and Kidney Transplantation, Hôpital de la Conception, Marseille, France.
Urology Department, Hospices Civils de Lyon (HCL), Hôpital Lyon SUD, Pierre-Bénite cedex, France.
Fr J Urol. 2024 Nov;34(11):102755. doi: 10.1016/j.fjurol.2024.102755.
Distal anterior urethral strictures (DAUS) affect the meatus, navicular fossa (NF) and penile urethra (PU). The main causes are inflammatory (lichen sclerosous [LS]), traumatic iatrogenic, or idiopathic. Post-hypospadias stenosis is common and constitutes a separate entity, dealt with in a separate article.
A summary of North American, European and French recommendations was drawn up, supplemented by a literature search from December 2020 to December 2023, to provide a current overview of strategies adapted to DAUS.
Stricture limited to the meatus without LS can be dilated once. From the 1st recurrence or in the presence of LS, only a ventral or dorsal meatoplasty will be effective. In cases of Navicular involvement, an augmentation urethroplasty, respecting the glans penis (aesthetic preservation) will be preferred. Severe cases or recurrences may require replacement urethroplasty in two or more stages. PU stricture should not be treated by endoscopic urethrotomy but by urethroplasty in all cases. A one-stage augmentation technique will be discussed with a staged (2 stages most often) urethroplasty depending on the severity of the obstruction, stricture length, recurrent nature and the presence of LS. Buccal mucosa (jugal, lingual) is the most commonly used material in the form of a free graft. The most complex cases may require a perineal urethrostomy.
DAUS present in a variety of ways. They are mainly managed surgically, in one or more stages. It is necessary to master several techniques to adapt to their heterogeneity.
远端前尿道狭窄(DAUS)影响尿道口、舟状窝(NF)和阴茎尿道(PU)。主要病因包括炎症(硬化性苔藓[LS])、创伤性医源性或特发性。尿道下裂后狭窄较为常见,构成一个单独的实体,将在另一篇文章中讨论。
总结了北美、欧洲和法国的推荐意见,并补充了 2020 年 12 月至 2023 年 12 月的文献检索,提供了适用于 DAUS 的策略的最新概述。
仅局限于尿道口且无 LS 的狭窄可扩张一次。首次复发或存在 LS 时,仅行腹侧或背侧尿道成形术有效。如果涉及舟状窝,将优先考虑保留龟头(美学保留)的尿道增宽术。严重病例或复发者可能需要分两期或多期行替代尿道成形术。PU 狭窄不应行内镜下尿道切开术,而应行尿道成形术。将根据梗阻严重程度、狭窄长度、复发性质和 LS 存在情况讨论一期增宽技术或分期(通常为两期)尿道成形术。颊黏膜(颊部、舌部)是最常用的游离移植物材料。最复杂的病例可能需要会阴尿道造口术。
DAUS 表现多样。它们主要通过手术治疗,一期或多期。需要掌握多种技术以适应其异质性。