Roberts Annette G, Kilpatrick Ryan, Diaz Lindsey D, Benjamin Scott, Espinoza Santiago Athziry J, Jallow Bubacarr, Monteith Madison F, Rumsey Sarah, Clark Reese H, Zimmerman Kanecia, Benjamin Daniel K, Greenberg Rachel G
Duke Clinical Research Institute, Durham, North Carolina.
Division of Newborn Medicine, Tufts University School of Medicine, Boston, Massachusetts.
Am J Perinatol. 2025 Jun;42(8):1017-1023. doi: 10.1055/a-2451-9925. Epub 2024 Nov 25.
This study aimed to analyze trends in gabapentin use in neonatal intensive care units (NICUs) and examine demographic characteristics, diagnoses, and concomitant medications associated with its use.Cohort study of 987,181 infants hospitalized in the NICU from 2005 to 2020.Eighty-five infants (<0.01%) received gabapentin. From 2009 to 2020, there was a 1,055% relative increase in gabapentin use ( < 0.01). The median birth weight was 2,160 g (25th, 75th percentiles: 875, 3,080 g) in gabapentin-exposed infants compared with 2,498 g (1,890, 3,210 g) in unexposed infants ( < 0.001). Over half (55%) of infants receiving gabapentin were born prematurely, 54% ( = 45) had chronic lung disease, 46% ( = 39) had gastrostomy tubes, and 34% ( = 29) had drug withdrawal syndrome; 49% ( = 42) and 27% ( = 23) received opioids and benzodiazepines, respectively.Use of gabapentin was rare but increased over time despite limited research on its safety and efficacy in infants, illuminating the need for further studies. · Gabapentin safety in infants is not well understood.. · Gabapentin use increased despite limited safety research.. · Further studies on gabapentin use in infants are needed..
本研究旨在分析新生儿重症监护病房（NICU）中加巴喷丁的使用趋势，并研究与其使用相关的人口统计学特征、诊断情况及合并用药。对2005年至2020年在NICU住院的987181名婴儿进行队列研究。85名婴儿（<0.01%）使用了加巴喷丁。从2009年到2020年，加巴喷丁的使用相对增加了1055%（<0.01）。使用加巴喷丁的婴儿中位出生体重为2160克（第25、75百分位数：875、3080克），未使用加巴喷丁的婴儿中位出生体重为2498克（1890、3210克）（<0.001）。使用加巴喷丁的婴儿中超过一半（55%）为早产儿，54%（n = 45）患有慢性肺病，46%（n = 39）有胃造瘘管，34%（n = 29）有药物戒断综合征；49%（n = 42）和27%（n = 23）的婴儿分别使用了阿片类药物和苯二氮䓬类药物。尽管对其在婴儿中的安全性和有效性研究有限，但加巴喷丁的使用虽罕见但呈上升趋势，这表明有必要进行进一步研究。· 婴儿使用加巴喷丁的安全性尚不清楚。· 尽管安全性研究有限，但加巴喷丁的使用仍在增加。· 需要对婴儿使用加巴喷丁进行进一步研究。
