Department of Medical Microbiology and Immunology, University of California Davis School of Medicine, Davis, CA, USA.
Adv Exp Med Biol. 2024;1465:89-97. doi: 10.1007/978-3-031-66686-5_6.
The epigenetic deregulations correlate with tumorigenesis, resistance to therapy, and metastasis of breast cancer cells. Given the predominance of aberrant epigenomic mechanisms, there is a growing emphasis on targeting epigenetic mechanisms for breast cancer therapeutic development. Selective inhibitors of epigenetic enzymes and the combined approach of epigenetic therapies with chemotherapies or hormone therapies in the treatment of breast cancer represent promising therapeutic strategies. In this chapter, we review the targeting of epigenetic mechanisms and highlight current epigenetic research in the development of breast cancer therapy.
表观遗传失调与乳腺癌细胞的肿瘤发生、治疗耐药和转移相关。鉴于异常表观基因组机制占主导地位，人们越来越重视针对表观遗传机制来开发乳腺癌治疗方法。针对表观遗传酶的选择性抑制剂以及将表观遗传疗法与化疗或激素疗法联合用于治疗乳腺癌代表了有前途的治疗策略。在本章中，我们综述了针对表观遗传机制的靶向治疗，并强调了当前在开发乳腺癌治疗方法方面的表观遗传研究。
