Department of Cardiovascular Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, Jiangxi, China.
Department of Cardiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Sci Rep. 2024 Nov 25;14(1):29155. doi: 10.1038/s41598-024-80790-8.
To examine the relationship between age at diagnosis of type 2 diabetes (T2DM) with cardiovascular and all-cause mortality in the U.S. population. Data was used from NHANES 1999 ~ 2018, which were screened to include a total of 8,654 participants with a diagnosis of diabetes for the study. We estimated the association between age at diagnosis and cardiovascular and all-cause mortality using weighted multivariate Cox regression analyses. Subgroup analyses and sensitivity analyses were performed to ensure the robustness of the data analysis. The number of participants diagnosed with diabetes at ages < 40, between 40 and 59, and > 60 are 1,492, 3,970, and 3,192, respectively, with median ages of 44.04, 57.59, and 72.24. Among patients diagnosed with T2DM, the relative risk of all-cause mortality increased with younger age at diagnosis: compared to patients with late-onset diabetes (age at type 2 diabetes diagnosis ≥ 60), the hazard ratio for all-cause mortality was 2.72 (95% CI 1.83-4.05) in those with early-onset diabetes (age at type 2 diabetes diagnosis < 40). Similarly, the risk of cardiovascular disease death was observed to be a higher relative risk with younger age at diagnosis. Exposure-effect analysis indicated that younger age at diagnosis is associated with higher risk of all-cause mortality. Subgroup analysis found that the association between age at diagnosis and cardiovascular and all-cause mortality was stronger in the current smokers and hypertensive population. The results of this study suggest that younger age at diagnosis of T2DM is associated with higher risk of death in patients. Younger patients diagnosed with T2DM had a higher risk of cardiovascular and all-cause mortality. These findings strengthen the understanding of the risk of death from T2DM and emphasize the importance of early prevention of diabetes.
为了研究美国人群中 2 型糖尿病（T2DM）发病年龄与心血管疾病和全因死亡率之间的关系。本研究使用了 1999 年至 2018 年的 NHANES 数据，这些数据经过筛选，共纳入了 8654 名被诊断为糖尿病的参与者。我们使用加权多变量 Cox 回归分析来估计发病年龄与心血管疾病和全因死亡率之间的关系。进行了亚组分析和敏感性分析，以确保数据分析的稳健性。在年龄<40 岁、40 岁至 59 岁和>60 岁被诊断为糖尿病的参与者人数分别为 1492、3970 和 3192，中位数年龄分别为 44.04、57.59 和 72.24。在被诊断为 T2DM 的患者中，全因死亡率的相对风险随着发病年龄的降低而增加：与发病年龄≥60 岁的晚发性糖尿病患者相比，发病年龄<40 岁的早发性糖尿病患者的全因死亡率的危险比为 2.72（95%CI 1.83-4.05）。同样，发病年龄越低，心血管疾病死亡的风险越高。暴露-效应分析表明，发病年龄越小，全因死亡率的风险越高。亚组分析发现，发病年龄与心血管疾病和全因死亡率之间的关系在当前吸烟者和高血压人群中更强。这项研究的结果表明，T2DM 的发病年龄越小，患者的死亡风险越高。年轻的 T2DM 患者有更高的心血管和全因死亡风险。这些发现加强了对 T2DM 死亡风险的认识，并强调了早期预防糖尿病的重要性。
