甘油三酯水平与重症监护患者 30 天死亡率相关：MIMIC-IV 数据库中的回顾性分析。
Triglyceride levels are associated with 30-day mortality in intensive care patients: a retrospective analysis in the MIMIC-IV database.
机构信息
Department of Emergency Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu Province, China.
Jiangsu Provincial Medical Innovation Center of Trauma Medicine, Suzhou, China.
出版信息
Eur J Med Res. 2024 Nov 26;29(1):561. doi: 10.1186/s40001-024-02159-x.
BACKGROUND
Previous studies suggest that septic patients often have elevated triglyceride levels due to various factors, and higher levels may indicate a poorer prognosis. However, few studies have investigated whether lower triglycerides are associated with a better prognosis.
METHODS
The Medical Information Mart for Intensive Care IV (MIMIC-IV) database provided all the data. To assess the association between triglycerides and prognosis, we used logistic regression analysis (LR), least absolute shrinkage and selection operator (LASSO) and Cox proportional hazards models.
RESULTS
Inclusion criteria were met by a total of 804 patients with a mean triglyceride of 103 mg/dL. We found that patients had a higher risk of 30-day ICU mortality when triglycerides were in the second quartile (74-103 mg/dL). Interestingly, this group of patients seems to benefit more from the use of atorvastatin.
CONCLUSION
Our study showed that septic patients with triglyceride levels in the second quartile (74-103 mg/dL) have a higher 30-day ICU mortality rate compared to those with triglyceride levels in other quartiles.
背景
先前的研究表明，由于各种因素，脓毒症患者的甘油三酯水平常常升高，而较高的水平可能预示着预后较差。然而，很少有研究探讨较低的甘油三酯是否与更好的预后相关。
方法
我们使用逻辑回归分析（LR）、最小绝对值收缩和选择算子（LASSO）以及 Cox 比例风险模型，从医疗信息监测与知识库第四版（MIMIC-IV）数据库中获取所有数据，以评估甘油三酯与预后之间的关联。
结果
共有 804 名甘油三酯平均值为 103mg/dL 的患者符合纳入标准。我们发现，甘油三酯处于第二四分位（74-103mg/dL）的患者，其 ICU 30 天死亡率的风险更高。有趣的是，这组患者似乎从使用阿托伐他汀中获益更多。
结论
我们的研究表明，与其他四分位的甘油三酯水平相比，处于第二四分位（74-103mg/dL）的脓毒症患者的 ICU 30 天死亡率更高。
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