Huang Rong, Zheng Rui, Fu Shui, Li Zuo Jie
Clinical Laboratory Department, First People's Hospital of Linping District, Hangzhou, Zhejiang Province, People's Republic of China.
Department of Central Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou, People's Republic of China.
Int J Gen Med. 2024 Nov 20;17:5443-5452. doi: 10.2147/IJGM.S489533. eCollection 2024.
Pertussis is a highly contagious respiratory disease, and early diagnosis and timely treatment are crucial for reducing complications and transmission. In this study, we analyzed the prevalence of pertussis and assessed the value of the WBC and lymphocyte percentage in its screening.
A retrospective analysis was conducted on global pertussis data from the past decade. Patients who recently underwent pertussis nucleic acid detection and complete blood count (CBC) in our hospital were selected. Based on the results, 538 patients were classified into the pertussis group, and 595 into the control group. White blood count (WBC) and lymphocyte percentages were compared, diagnostic efficacy was calculated, and evaluate their application value in the diagnosis of pertussis.
In the past decade, the global incidence of pertussis first decreased, then increased. In China and Zhejiang province, it fluctuated but showed an upward trend recently. In Zhejiang Province, pertussis was more prevalent in summer and winter and rose last year. Between 2018 and 2020, most pertussis cases in China were infants under 1 year old. Last year, only 1.12% of patients in our hospital were infants, with more patients over 5 years old. WBC, lymphocyte percentage, and platelet count (PLT) was higher in the pertussis group (P < 0.05). Logistic regression showed that WBC, lymphocyte percentage, and PLT were correlated with pertussis infection. Sequential analysis showed that the WBC, lymphocyte percentage, and Youden's index for both combined were 0.124, 0.082, and 0.044, respectively.
The global incidence of pertussis is rising, with significant increases among adolescents and adults. Improved prevention and control strategies are needed. WBC and lymphocyte percentage serve as auxiliary diagnostic indicators, but their efficacy is limited.
百日咳是一种高度传染性的呼吸道疾病，早期诊断和及时治疗对于减少并发症和传播至关重要。在本研究中，我们分析了百日咳的患病率，并评估了白细胞计数（WBC）和淋巴细胞百分比在其筛查中的价值。
对过去十年的全球百日咳数据进行回顾性分析。选取我院近期接受百日咳核酸检测和全血细胞计数（CBC）的患者。根据结果，将538例患者分为百日咳组，595例分为对照组。比较白细胞计数（WBC）和淋巴细胞百分比，计算诊断效能，并评估它们在百日咳诊断中的应用价值。
在过去十年中，全球百日咳发病率先下降后上升。在中国和浙江省，发病率有波动但近期呈上升趋势。在浙江省，百日咳在夏季和冬季更为流行，且去年有所上升。2018年至2020年，中国大多数百日咳病例为1岁以下婴儿。去年，我院只有1.12%的患者为婴儿，5岁以上患者更多。百日咳组的白细胞计数（WBC）、淋巴细胞百分比和血小板计数（PLT）更高（P<0.05）。Logistic回归显示，白细胞计数（WBC）、淋巴细胞百分比和血小板计数（PLT）与百日咳感染相关。序贯分析显示，两者联合的白细胞计数（WBC）、淋巴细胞百分比和约登指数分别为0.124、0.082和0.044。
全球百日咳发病率正在上升，青少年和成年人中有显著增加。需要改进防控策略。白细胞计数（WBC）和淋巴细胞百分比可作为辅助诊断指标，但其效能有限。
