Gerdes J S, Yoder M C, Douglas S D, Paul M, Harris M C, Polin R A
J Pediatr. 1986 Apr;108(4):601-6. doi: 10.1016/s0022-3476(86)80847-2.
Plasma for fibronectin determinations was obtained from 39 neonates with uncomplicated respiratory distress syndrome (RDS) and from 15 infants with RDS who developed bronchopulmonary dysplasia (BPD). Tracheal lavage fibronectin and albumin concentrations were measured in 15 infants with RDS and 15 with BPD. Control plasma fibronectin values were obtained from 20 healthy preterm infants on days 1, 2, 3, 14, and 30 of life. Control tracheal lavage fibronectin and albumin concentrations were measured in 17 neonates of various gestational ages who required tracheal intubation for nonpulmonary indications. Mean plasma fibronectin concentrations from patients with RDS was 121 +/- 11 micrograms/ml on days 1, 2, and 3, versus control level of 163 +/- 12 micrograms/ml (P less than 0.01). Mean tracheal lavage fibronectin/albumin ratio was 3.8 +/- 0.6 ng per microgram of albumin on days 1 to 5 for infants with RDS, versus control level of 5.6 +/- 3.6 (P = NS). Tracheal lavage fibronectin/albumin ratio from patients with BPD was elevated at 16.3 +/- 5.0 ng fibronectin per microgram of albumin on days 14 to 21, and 23.6 +/- 7.4 on day 30 (P less than 0.05 versus control and and versus RDS days 1 to 10). Low plasma fibronectin concentrations early in RDS may contribute to the development of pulmonary capillary leak. High tracheal lavage fibronectin levels may foster the development of pulmonary fibrosis in patients with BPD.
用于纤连蛋白测定的血浆取自39例患单纯呼吸窘迫综合征（RDS）的新生儿以及15例患RDS且并发支气管肺发育不良（BPD）的婴儿。测定了15例患RDS的婴儿和15例患BPD的婴儿气管灌洗中的纤连蛋白和白蛋白浓度。从20例健康早产儿出生后第1、2、3、14和30天获取对照血浆纤连蛋白值。在17例因非肺部指征需要气管插管的不同胎龄新生儿中测定了对照气管灌洗纤连蛋白和白蛋白浓度。患RDS患者第1、2和3天的血浆纤连蛋白平均浓度为121±11微克/毫升，而对照水平为163±12微克/毫升（P<0.01）。患RDS婴儿第1至5天气管灌洗纤连蛋白/白蛋白平均比值为每微克白蛋白3.8±0.6纳克，而对照水平为5.6±3.6（P=无显著性差异）。患BPD患者气管灌洗纤连蛋白/白蛋白比值在第14至21天升高至每微克白蛋白16.3±5.0纳克纤连蛋白，第30天为23.6±7.4（与对照相比以及与RDS第1至10天相比，P<0.05）。RDS早期血浆纤连蛋白浓度低可能导致肺毛细血管渗漏的发生。气管灌洗纤连蛋白水平高可能促进BPD患者肺纤维化的发展。
