Badash Ido, Wong Stephanie, Biju Kevin, Hur Kevin, Commesso Emily, Kezirian Eric J
Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Department of Head and Neck Surgery and Communication Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Otolaryngol Head Neck Surg. 2025 Feb;172(2):678-685. doi: 10.1002/ohn.1069. Epub 2024 Nov 26.
To examine the effect of perioperative celecoxib and acetaminophen administration on opioid consumption in the first 24 hours after palate surgery for obstructive sleep apnea (OSA).
Retrospective cohort study.
Tertiary academic center.
Adults with OSA undergoing soft palate surgery and admitted to the hospital postoperatively between July 2013 and June 2023 were included. Study participants were also included if they underwent concurrent nasal surgery but excluded if they underwent any pharyngeal surgery other than tonsillectomy or were taking opioids prior to surgery. Opioids administered after surgery were converted to morphine milligram equivalents (MME). Multiple linear regression was used to examine the association between total MME consumed in the first 24 hours postoperatively and celecoxib and acetaminophen usage.
A total of 210 study participants (15.7% female) were included with a mean age of 48.8 ± 37.5 years. The mean MME consumed in the first 24 hours after palate surgery was 80.2 ± 63.9. One hundred and twenty-six (60%) study participants received perioperative celecoxib, while 195 (93%) received perioperative acetaminophen. Celecoxib use was associated with lesser MME (-2.7 ± 1.1 MME per 100 mg; P = .018) consumed postoperatively, while acetaminophen was not (-0.3 ± 0.3 MME per 100 mg; P = .43). Female gender, Asian race, and African American race were also associated with lesser MME consumed postoperatively, while autoimmune/immunosuppressive conditions and tonsillectomy were associated with greater MME consumption.
Perioperative celecoxib was associated with reduced MME consumption in the first 24 hours after palate surgery. No association was found between acetaminophen and postoperative opioid use.
探讨围手术期服用塞来昔布和对乙酰氨基酚对阻塞性睡眠呼吸暂停（OSA）腭部手术后24小时内阿片类药物消耗量的影响。
回顾性队列研究。
三级学术中心。
纳入2013年7月至2023年6月期间接受软腭手术并术后入院的成年OSA患者。如果患者同时接受了鼻腔手术也纳入研究，但如果患者接受了除扁桃体切除术以外的任何咽部手术或术前服用阿片类药物则排除。术后使用的阿片类药物换算为吗啡毫克当量（MME）。采用多元线性回归分析术后24小时内消耗的总MME与塞来昔布和对乙酰氨基酚使用之间的关联。
共纳入210名研究参与者（15.7%为女性），平均年龄48.8±37.5岁。腭部手术后24小时内平均消耗的MME为80.2±63.9。126名（60%）研究参与者围手术期服用塞来昔布，195名（93%）服用围手术期对乙酰氨基酚。使用塞来昔布与术后消耗较少的MME相关（每100 mg -2.7±1.1 MME；P = 0.018），而对乙酰氨基酚则不然（每100 mg -0.3±0.3 MME；P = 0.43）。女性、亚洲种族和非裔美国人种族也与术后消耗较少的MME相关，而自身免疫/免疫抑制疾病和扁桃体切除术与较高的MME消耗相关。
围手术期使用塞来昔布与腭部手术后24小时内MME消耗量减少有关。未发现对乙酰氨基酚与术后阿片类药物使用之间存在关联。
