Lingua R W, Azen S P, Walonker F, Levin L, Baker S
J Pediatr Ophthalmol Strabismus. 1986 Mar-Apr;23(2):69-73. doi: 10.3928/0191-3913-19860301-06.
Succinylcholine was injected intraoperatively in 41 strabismus patients with congenital esotropia or intermittent or constant exotropia. Regression analyses were performed to investigate the predictive relationships between the one-, six-, and 26-week postoperative alignment and the intraoperative, succinylcholine-induced ocular position. Ocular position, determined by the interlimbal distance in millimeters, was calculated using a semi-automated, video replay analysis system. Large, statistically significant correlation coefficients were obtained for patients undergoing bimedial recessions of 4.0 to 5.5 mm and bilateral lateral rectus recessions of 5.0 to 7.0 mm. Small correlations were obtained for esotropes undergoing the recession/resection procedure and those with bimedial recessions of 6.0 mm or greater. These data support the theory that the succinylcholine-sensitive subgroup of the extraocular muscle fibers are those whose tonic contracture provide the motor component to ocular alignment. Sample sizes at present are insufficient to suggest clinical use of these data. In future research, these relationships will be tested for their ability to predict postoperative alignment and thereby, improve success rates in strabismus surgery.
41例患有先天性内斜视或间歇性或恒定性外斜视的斜视患者在术中注射了琥珀酰胆碱。进行回归分析以研究术后1周、6周和26周的眼位矫正与术中琥珀酰胆碱诱导的眼位之间的预测关系。眼位通过毫米为单位的角膜缘间距离确定，使用半自动视频回放分析系统进行计算。对于接受4.0至5.5毫米双侧内直肌后徙和5.0至7.0毫米双侧外直肌后徙的患者，获得了较大的、具有统计学意义的相关系数。对于接受后徙/切除术的内斜视患者以及双侧内直肌后徙6.0毫米或更大的患者，获得的相关性较小。这些数据支持以下理论：眼外肌纤维中对琥珀酰胆碱敏感的亚组是那些其强直性收缩为眼位矫正提供运动成分的亚组。目前的样本量不足以表明这些数据可用于临床。在未来的研究中，将测试这些关系预测术后眼位矫正的能力，从而提高斜视手术的成功率。
