Ziegler M M, Kirby J, McCarrick J W, Ikeda C B, Dasher J
J Pediatr Surg. 1986 Mar;21(3):236-9. doi: 10.1016/s0022-3468(86)80842-9.
The nutritional sequelae of neuroblastoma are secondary to tumor burden, tumor-host influenced metabolism, and antitumor operative, pharmacologic, and radiation therapy. Nutritional support and its influence on the outcome of clinical cancer is confusing; but in a defined murine system, we hypothesized that whether or not nutritional repletion favors the host-tumor relationship is dependent on a nutritional augmentation of host antitumor immunity. C1300 murine neuroblastoma (NB) elicits a host antitumor immune response as determined by in vivo and in vitro testing; but the TBJ clone of the same tumor is nonimmunogenic. After receiving two weeks of either regular 24% protein or protein restricted 2.5% protein chow, normal and malnourished mice received either C1300-NB or TBJ-NB and were serially followed to animal death. The median survival time (MST) of TBJ recipients was shorter in this more aggressive tumor, but the MST of 27.5 days was equal for normal and malnourished mice. Contrasting with these data were an MST of 38 days for malnourished C1300 NB recipients and an MST of 64.5 days for normally nourished C1300 NB recipients, values that are significantly different (P less than 0.02). These data suggest that nutritional support influencing host antitumor immunity may be of benefit only in that circumstance where the tumor elicits an antitumor immune response.
神经母细胞瘤的营养后遗症继发于肿瘤负荷、肿瘤-宿主相互影响的代谢以及抗肿瘤手术、药物治疗和放射治疗。营养支持及其对临床癌症结局的影响尚不明确；但在一个明确的小鼠系统中，我们推测营养补充是否有利于宿主-肿瘤关系取决于宿主抗肿瘤免疫力的营养增强。C1300小鼠神经母细胞瘤（NB）通过体内和体外测试显示能引发宿主抗肿瘤免疫反应；但同一肿瘤的TBJ克隆无免疫原性。在接受两周常规24%蛋白质或蛋白质限制为2.5%蛋白质的饲料后，正常和营养不良的小鼠分别接种C1300-NB或TBJ-NB，并连续观察直至动物死亡。在这种侵袭性更强的肿瘤中，TBJ接种小鼠的中位生存时间（MST）较短，但正常和营养不良小鼠的MST均为27.5天。与这些数据形成对比的是，营养不良的C1300 NB接种小鼠的MST为38天，正常营养的C1300 NB接种小鼠的MST为64.5天，这两个值有显著差异（P小于0.02）。这些数据表明，影响宿主抗肿瘤免疫力的营养支持可能仅在肿瘤引发抗肿瘤免疫反应的情况下有益。
