血清胃泌素水平与自身免疫性化生萎缩性胃炎中神经内分泌肿瘤的患病率相关。
Serum Gastrin Levels Are Associated With Prevalent Neuroendocrine Tumors in Autoimmune Metaplastic Atrophic Gastritis.
作者信息
Jove Andre, Lin Christina, Hwang Joo Ha, Balasubramanian Vidhya, Fernandez-Becker Nielsen Q, Huang Robert J
机构信息
Department of Medicine, Stanford University, Stanford, California, USA.
Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California, USA .
出版信息
Am J Gastroenterol. 2025 May 1;120(5):1140-1143. doi: 10.14309/ajg.0000000000003235. Epub 2024 Nov 26.
Abstract
INTRODUCTION
Autoimmune metaplastic atrophic gastritis (AMAG) is a precancerous condition that predisposes to gastric neuroendocrine tumors (gNETs). There exist no methods to stratify patients with AMAG for gNET risk.
METHODS
We identified a cohort of patients with AMAG within a university health system using histopathologic and serologic criteria. We analyzed features predictive of prevalent gNET.
RESULTS
We identified 181 patients with AMAG and 41 (22.7%) with prevalent gNET. Gastrin levels were elevated in gNET (1,859.8 vs 679.5 pg/mL, P < 0.001), and gastrin titers demonstrated good discrimination (c = 0.799, 95% CI 0.707-0.892) for gNET.
DISCUSSION
Gastrin levels differ significantly between patients with AMAG with and without gNET.
摘要
引言
自身免疫性化生萎缩性胃炎（AMAG）是一种癌前病变，易引发胃神经内分泌肿瘤（gNETs）。目前尚无对AMAG患者进行gNET风险分层的方法。
方法
我们在大学卫生系统内根据组织病理学和血清学标准确定了一组AMAG患者。我们分析了预测gNETs患病率的特征。
结果
我们确定了181例AMAG患者，其中41例（22.7%）患有gNETs。gNET患者的胃泌素水平升高（1,859.8对679.5 pg/mL，P < 0.001），胃泌素滴度对gNET具有良好的鉴别能力（c = 0.799，95% CI 0.707 - 0.892）。
讨论
患有和未患有gNET的AMAG患者之间胃泌素水平存在显著差异。
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