明智选择：A 组链球菌侵袭性感染密切接触者抗生素预防的有效性和安全性
Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection.
作者信息
Birck Marina G, Moura Cristiano S, Winthrop Kevin L, Machado Marina A A, Neville Autumn, Bernatsky Sasha
机构信息
Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Department of Medicine, McGill University, Montreal, Quebec, Canada.
出版信息
Clin Infect Dis. 2025 Feb 24;80(2):314-315. doi: 10.1093/cid/ciae524.
Antibiotic prophylaxis is often recommended for close contacts of index cases of invasive Streptococcus pyogenes infections. Using MarketScan data (2010-2019), we found no difference in infection rates between those who received and those who did not receive antibiotics but a 3-fold increased risk of adverse events in those who did receive antibiotics.
对于侵袭性化脓性链球菌感染的首例病例的密切接触者，通常建议进行抗生素预防。利用市场扫描数据（2010 - 2019年），我们发现接受抗生素治疗和未接受抗生素治疗的人群之间感染率没有差异，但接受抗生素治疗的人群发生不良事件的风险增加了3倍。
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