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明智选择：A 组链球菌侵袭性感染密切接触者抗生素预防的有效性和安全性

Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection.

作者信息

Birck Marina G, Moura Cristiano S, Winthrop Kevin L, Machado Marina A A, Neville Autumn, Bernatsky Sasha

机构信息

Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

Department of Medicine, McGill University, Montreal, Quebec, Canada.

出版信息

Clin Infect Dis. 2025 Feb 24;80(2):314-315. doi: 10.1093/cid/ciae524.

DOI:10.1093/cid/ciae524
PMID:39589137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11848273/
Abstract

Antibiotic prophylaxis is often recommended for close contacts of index cases of invasive Streptococcus pyogenes infections. Using MarketScan data (2010-2019), we found no difference in infection rates between those who received and those who did not receive antibiotics but a 3-fold increased risk of adverse events in those who did receive antibiotics.

摘要

对于侵袭性化脓性链球菌感染的首例病例的密切接触者，通常建议进行抗生素预防。利用市场扫描数据（2010 - 2019年），我们发现接受抗生素治疗和未接受抗生素治疗的人群之间感染率没有差异，但接受抗生素治疗的人群发生不良事件的风险增加了3倍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7d/11848273/efa900500689/ciae524_ga.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7d/11848273/efa900500689/ciae524_ga.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7d/11848273/efa900500689/ciae524_ga.jpg

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Emerg Infect Dis. 2023 May;29(5):898-908. doi: 10.3201/eid2905.221421.
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Effectiveness and Safety of Antibiotic Prophylaxis for Persons Exposed to Cases of Invasive Group A Streptococcal Disease: A Systematic Review.侵袭性A群链球菌病病例接触者抗生素预防的有效性和安全性：一项系统评价
Open Forum Infect Dis. 2022 May 12;9(8):ofac244. doi: 10.1093/ofid/ofac244. eCollection 2022 Aug.
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Patterns of Antibiotic Nonsusceptibility Among Invasive Group A Streptococcus Infections-United States, 2006-2017.
2006-2017 年美国侵袭性 A 组链球菌感染的抗生素耐药模式。
Clin Infect Dis. 2021 Dec 6;73(11):1957-1964. doi: 10.1093/cid/ciab575.
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Invasive Streptococcus pyogenes disease in Spain: a microbiological and epidemiological study covering the period 2007-2019.西班牙侵袭性化脓性链球菌病：一项涵盖 2007-2019 年期间的微生物学和流行病学研究。
Eur J Clin Microbiol Infect Dis. 2021 Nov;40(11):2295-2303. doi: 10.1007/s10096-021-04279-2. Epub 2021 May 27.
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