INSERM U1030, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-SANTE/SERAMED/LRMed, Fontenay-aux-Roses, France.
Oncoimmunology. 2024 Dec 31;13(1):2434280. doi: 10.1080/2162402X.2024.2434280. Epub 2024 Nov 26.
We recently demonstrated that a heterogeneous tumor irradiation strategy, combining high-dose and low-dose radiotherapy (RT) within the same tumor volume, can synergize with immunotherapy in mice. Our findings indicate that heterogeneous RT doses may promote the spatial diversification of the antitumor immune response. Spatial fractionation of the RT dose has the potential to enhance the therapeutic index of RT/IO combinations, particularly in scenarios where irradiating the entire tumor volume is unfeasible or excessively harmful to the patient.
我们最近证明，在同一肿瘤体积内结合高剂量和低剂量放疗（RT）的异质性肿瘤照射策略可以与免疫疗法在小鼠中协同作用。我们的研究结果表明，异质性 RT 剂量可能促进抗肿瘤免疫反应的空间多样化。RT 剂量的空间分割有可能提高 RT/IO 联合治疗的治疗指数，特别是在整个肿瘤体积照射不可行或对患者过于有害的情况下。
